Evidence map›Paper›PMID 34358078›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Antiviral Activity of Isoquinolone Derivatives against Influenza Viruses and Their Cytotoxicity.

Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho, Meehyein Kim

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Synthesis and biological evaluation of new β-D-NBioorganic & medicinal chemistry letters · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yejin JangInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Jinhe HanCollege of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
Xiaoli LiCollege of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
Hyunjin ShinInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.
Won-Jea ChoCollege of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
Meehyein KimInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Korea.ORCID 0000-0002-2851-5298
Chonnam National University · KRKorea Research Institute of Chemical Technology · KRChungnam National University · KR

Funding

Korea Research Institute of Chemical Technology SI2132-20National Research Foundation of Korea 2018M3A9H4089602National Research Foundation of Korea NRF-2018M3A9H4089601
6 · The paper itself

Abstract

Influenza viruses are one of the major causative agents for human respiratory infections. Currently, vaccines and antivirals approved for preventing and treating viral infections are available. However, limited protection efficacy and frequent emergence of drug-resistant viruses stand for a need for the development of antivirals with different chemical skeletons from existing drugs. Screening of a chemical library identified an isoquinolone compound (

Indexed as

antiviralinfluenza virusisoquinolone

Identifiers

PMID34358078
PMCPMC8308780
OpenAlexW3182083711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.