Evidence map›Paper›PMID 34358064›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Novel Purine Chemotypes with Activity against

Nieves Martinez-Peinado, Álvaro Lorente-Macías, Alejandro García-Salguero, Nuria Cortes-Serra, Ángel Fenollar-Collado, Albert Ros-Lucas, Joaquim Gascon, Maria-Jesus Pinazo, Ignacio J Molina, Asier Unciti-Broceta and 4 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. IntegratedPharmaceuticals (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Identification of novel compounds againstComputational and structural biotechnology journal · 2025
    Article
  7. Review
  8. Identification of compounds with activity againstFrontiers in cellular and infection microbiology · 2022
    Article
  9. Compounds targeting GPI biosynthesis orComputational and structural biotechnology journal · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Nieves Martinez-PeinadoBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-7107-5374
Álvaro Lorente-MacíasDepartment of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry Applied to Biomedicine and the Environment", Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071 Granada, Spain.ORCID 0000-0001-9510-714X
Alejandro García-SalgueroBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.
Nuria Cortes-SerraBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-5396-3757
Ángel Fenollar-ColladoBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.
Albert Ros-LucasBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-1003-5376
Joaquim GasconBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.
Maria-Jesus PinazoBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-4237-1075
Ignacio J MolinaInstitute of Biopathology and Regenerative Medicine, Centre for Biomedical Research, University of Granada, Avda. del Conocimiento s/n, 18100 Granada, Spain.
Asier Unciti-BrocetaCancer Research UK Edinburgh Centre, Institute of Genetics & Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.ORCID 0000-0003-1029-2855
Juan J Díaz-MochónDepartment of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry Applied to Biomedicine and the Environment", Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071 Granada, Spain.
María J Pineda de Las Infantas Y VillatoroDepartment of Medicinal & Organic Chemistry and Excellence Research Unit of "Chemistry Applied to Biomedicine and the Environment", Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, 18071 Granada, Spain.ORCID 0000-0002-0617-6408
Luis IzquierdoBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-3704-9874
Julio Alonso-PadillaBarcelona Institute for Global Health (ISGlobal), Hospital Clínic-University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0003-4466-7969
Barcelona Institute for Global Health · ESUniversidad de Granada · ESEdinburgh Cancer Research · GB

Funding

Carlos III Health Institute (ISCIII) RICET Network for Cooperative Research in Tropical Diseases RD12/0018/0010 and FEDERGeneralitat of Catalonia "CERCA Program"Generalitat of Catalonia Department of Health PERIS 2016-2010 SLT008/18/00132Generalitat of Catalonia Universities and Research Department 2017SGR00924ISCIII PI18/01054Spanish Ministry of Economy SAF2016-76080-RSpanish Ministry of Education, Culture and Sports FPU grant ref. 14/00818Spanish Ministry of Science & Innovation PID2019-110810RB-I00the Spanish Ministry of Science, Innovation and Universities "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S)
6 · The paper itself

Abstract

Malaria and Chagas disease, caused by

Indexed as

cytotoxicity assaysphenotypic assaysPlasmodium falciparumpurine derivativespurine metabolismpyrimidine analogsTrypanosoma cruzi

Identifiers

PMID34358064
PMCPMC8308784
OpenAlexW3173609291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.