ArticlePathogens (Basel, Switzerland)2021
Successful Eradication of Porcine Epidemic Diarrhea in an Enzootically Infected Farm: A Two-Year Follow-Up Study.
Article in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- In Vitro and In Vivo Evaluation ofAnimals : an open access journal from MDPI · 2025Article
- Comparison of Vaccination Regimens on Immune Responses Using PED Replicon Vaccine: A Field Trial in PED-Negative and PED-Positive Thai Swine Farms.Animals : an open access journal from MDPI · 2025Article
- Genotypic characterization of novel S-DEL variants of porcine epidemic diarrhea virus identified in South Korea.Archives of virology · 2024Article
- Effectiveness of gilt acclimatization - improvement procedures in a farm with recurrent outbreaks of porcine epidemic diarrhea.Veterinary world · 2023Article
- Reverse Genetic Assessment of the Roles Played by the Spike Protein and ORF3 in Porcine Epidemic Diarrhea Virus Pathogenicity.Journal of virology · 2023Article
- Porcine epidemic diarrhea virus: an update overview of virus epidemiology, vaccines, and control strategies in South Korea.Journal of veterinary science · 2023Review
- Coinfection with porcine epidemic diarrhea virus and Clostridium perfringens type A enhances disease severity in weaned pigs.Archives of virology · 2023Article
- Phylogenetic and Spatiotemporal Analyses of Porcine Epidemic Diarrhea Virus in Guangxi, China during 2017-2022.Animals : an open access journal from MDPI · 2023Article
- Genomic and Virulence Investigations of a Novel Porcine Deltacoronavirus Strain Identified in South Korea.Transboundary and emerging diseases · 2023Article
- A discrete-time survival model for porcine epidemic diarrhoea virus.Transboundary and emerging diseases · 2022Article
- Molecular analysis reveals a distinct subgenogroup of porcine epidemic diarrhea virus in northern Vietnam in 2018-2019.Archives of virology · 2022Article
- Development of a Next-Generation Vaccine Platform for Porcine Epidemic Diarrhea Virus Using a Reverse Genetics System.Viruses · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Porcine epidemic diarrhea virus (PEDV) has negatively affected the welfare of animals and their productivity in South Korea for three decades. A shortage of effective control measures has led to the virus becoming endemic in domestic pig populations. This study aimed to describe how our intervention measures were implemented for PEDV elimination in an enzootically infected farm. We operated a risk assessment model of PEDV recurrence to obtain information about the virus itself, herd immunity, virus circulation, and biosecurity at the farm. Next, we conducted a four-pillar-based two-track strategy to heighten sow immunity and eradicate the virus, with longitudinal monitoring of immunity and virus circulation, involving strict biosecurity, prime-boost pre-farrow L/K/K immunization, all-in-all-out and disinfection practices in farrowing houses, and disinfection and gilt management in wean-to-finish barns. In particular, we observed a high prevalence and long-term survival of PEDV in slurries, posing a critical challenge to PED eradication and highlighting the necessity for consecutive testing of barn slurry samples and for the management of infected manure to control PEDV. Genetic analysis of PEDVs in this farm indicated that genetic drift continued in the spike gene, with a substitution rate of 1.683 × 10
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