Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling.
Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors at 5 institutions in 2 countries.
Tarek Mohamed Abd El-AzizDepartment of Cellular & Integrative Physiology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0002-3441-9673
Yucheng XiaoDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Jake KlineDepartment of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.ORCID 0000-0001-7264-7637
Harold GridleyDepartment of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.
Alyse HeastonDepartment of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.
Klaus D LinseBio-Synthesis Inc., 612 E. Main Street, Lewisville, TX 75057, USA.
Micaiah J WardDepartment of Biological Sciences, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306, USA.ORCID 0000-0001-9474-8615
Darin R RokytaDepartment of Biological Sciences, Florida State University, 319 Stadium Drive, Tallahassee, FL 32306, USA.ORCID 0000-0002-0356-2178
James D StockandDepartment of Cellular & Integrative Physiology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.
Theodore R CumminsDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Luca FornelliDepartment of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.ORCID 0000-0001-6334-1046
Ashlee H RoweDepartment of Biology, University of Oklahoma, 730 Van Vleet Oval, Norman, OK 73019, USA.
University of Oklahoma · USFlorida State University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Indianapolis · USBio-Synthesis (United States) · US
Funding
Structure-Function Studies of MsvR, a Methanogen-Specific Transcriptional RegulaP20GM103640 · NIGMS · UNIVERSITY OF OKLAHOMA · PI THOMAS, LEONARD M · 2012 to 2021
$20.4M
Sodium channels and electrogenesis in sensory neuronsR01NS053422 · NINDS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CUMMINS, THEODORE R · 2006 to 2019
$4.6M
A novel mechanism of resurgent current generation in nociceptive sensory neuronsR21NS109896 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI XIAO, YUCHENG · 2019 to 2019
The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lack of biochemical tools for examining Nav1.8 gating mechanisms. Arizona bark scorpion (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling. · full record | OpenQuestion