Evidence map›Paper›PMID 34357967›Full record

ReviewToxins2021

Phthalic Acid Esters: Natural Sources and Biological Activities.

Ling Huang, Xunzhi Zhu, Shixing Zhou, Zhenrui Cheng, Kai Shi, Chi Zhang, Hua Shao

Abstract readReview
In one paragraph

Review in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed.

  1. Trial
  2. Article
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  5. Article
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  9. Article
  10. Pathogenic effects ofApplied and environmental microbiology · 2026
    Article
  11. Article
  12. Phthalate-induced effects in algae and fishes: insights into environmental toxicology.Environmental science and pollution research international · 2026
    Review
  13. Review
  14. The Biochemical Role of Bitter Melon (Food science & nutrition · 2026
    Article
  15. Article
  16. NutraceuticalCurrent pharmaceutical design · 2026
    Article
  17. Article
  18. Production and characterization of biosurfactant producing actinobacteria Streptomyces sp. AS1: a sustainable approach for crude oil degradation.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  19. Anticancer Effects of Sacha Inchi (International journal of molecular sciences · 2025
    Article
  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ling HuangState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China.
Xunzhi ZhuInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.
Shixing ZhouState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China.
Zhenrui ChengState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China.
Kai ShiState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China.
Chi ZhangShandong Provincial Key Laboratory of Water and Soil Conservation and Environmental Protection, College of Resources and Environment, Linyi University, Linyi 276000, China.ORCID 0000-0003-4866-1441
Hua ShaoState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China.ORCID 0000-0002-6206-921X

Funding

National Natural Science Foundation of China 31770586Open Fund of Shandong Provincial Key Laboratory of Water and Soil Conservation and Envi-ronmental Protection, China STKF201935Taishan Scholars Program of Shandong, China ts201712071
6 · The paper itself

Abstract

Phthalic acid esters (PAEs) are a class of lipophilic chemicals widely used as plasticizers and additives to improve various products' mechanical extensibility and flexibility. At present, synthesized PAEs, which are considered to cause potential hazards to ecosystem functioning and public health, have been easily detected in the atmosphere, water, soil, and sediments; PAEs are also frequently discovered in plant and microorganism sources, suggesting the possibility that they might be biosynthesized in nature. In this review, we summarize that PAEs have not only been identified in the organic solvent extracts, root exudates, and essential oils of a large number of different plant species, but also isolated and purified from various algae, bacteria, and fungi. Dominant PAEs identified from natural sources generally include di-

Indexed as

AgricultureChinaDibutyl PhthalateDiethylhexyl PhthalateEcosystemEnvironmental PollutantsEstersHumansPhthalic AcidsPlasticizersSoilSoil PollutantsDibutyl PhthalateDiethylhexyl Phthalatediethyl phthalatediisobutyl phthalatediisooctyl phthalatedimethyl phthalateEnvironmental PollutantsEstersphthalic acidPhthalic AcidsPlasticizersSoilSoil Pollutantsbiological activitydi(2-ethylhexyl) phthalatedi-n-butyl phthalatenatural sourcesphthalic acid esters

Identifiers

PMID34357967
PMCPMC8310026

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.