Evidence map›Paper›PMID 34357951›Full record

ArticleToxins2021

Circulating

Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Kuo-Cheng Lu, Cai-Mei Zheng, Mai-Szu Wu, Shu-Wei Chang, Ting-Ming Wang, Chang-Chin Wu

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Bone turnover markers in the management of CKD-associated osteoporosis-a European consensus.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jia-Feng ChangDivision of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan.ORCID 0000-0002-9903-7473
Chih-Yu HsiehSchool of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-9770-6779
Jian-Chiun LiouSchool of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.
Kuo-Cheng LuDivision of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan.ORCID 0000-0002-7062-8560
Cai-Mei ZhengDivision of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.ORCID 0000-0003-0370-3951
Mai-Szu WuDivision of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, Taiwan.
Shu-Wei ChangDepartment of Civil Engineering, National Taiwan University, Taipei 106, Taiwan.
Ting-Ming WangDepartment of Orthopaedic Surgery, School of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-2263-5993
Chang-Chin WuDepartment of Orthopaedic Surgery, National Taiwan University Hospital, Taipei 100, Taiwan.
National Taiwan University · TWTaipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWYuanpei University · TWTaipei Tzu Chi Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 109-2628-B-385 -001
6 · The paper itself

Abstract

Patients with chronic kidney disease (CKD), especially those undergoing hemodialysis, are at a considerably high risk of bone fracture events. Experimental data indicate that uremic toxins intricately involved in bone-related proteins exert multi-faced toxicity on bone cells and tissues, leading to chronic kidney disease-mineral and bone disorder (CKD-MBD). Nonetheless, information regarding the association between

Indexed as

Alkaline PhosphataseBiomarkersBone and BonesBone DiseasesCresolsFractures, BoneHumansIndicanMiddle AgedMineralsRenal DialysisRenal Insufficiency, ChronicSulfatesSulfuric Acid EstersToxins, BiologicalUremia4-cresol sulfateAlkaline PhosphataseBiomarkersCresolsIndicanMineralsSulfatesSulfuric Acid EstersToxins, BiologicalUremic Toxinsalkaline phosphatasebone fracturechronic kidney disease–mineral and bone disorderp-cresyl sulfate

Identifiers

PMID34357951
PMCPMC8310177
OpenAlexW3180463675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.