Evidence map›Paper›PMID 34357949›Full record

ArticleToxins2021

Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease.

Beatriz Arce-López, Lydia Alvarez-Erviti, Barbara De Santis, María Izco, Silvia López-Calvo, Maria Eugenia Marzo-Sola, Francesca Debegnach, Elena Lizarraga, Adela López de Cerain, Elena González-Peñas and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Beatriz Arce-LópezDepartment of Pharmaceutical Technology and Chemistry, Research Group MITOX, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain.
Lydia Alvarez-ErvitiLaboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3rd Floor, 26006 Logroño, Spain.ORCID 0000-0002-1238-9442
Barbara De SantisNational Reference Laboratory for Mycotoxins and Plant Toxins, Istituto Superiore di Sanità, 00161 Roma, Italy.ORCID 0000-0003-4210-2796
María IzcoLaboratory of Molecular Neurobiology, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3rd Floor, 26006 Logroño, Spain.ORCID 0000-0003-4807-6779
Silvia López-CalvoServicio de Neurología, Hospital San Pedro, Piqueras 98, 26006 Logroño, Spain.
Maria Eugenia Marzo-SolaServicio de Neurología, Hospital San Pedro, Piqueras 98, 26006 Logroño, Spain.
Francesca DebegnachNational Reference Laboratory for Mycotoxins and Plant Toxins, Istituto Superiore di Sanità, 00161 Roma, Italy.ORCID 0000-0002-8447-5948
Elena LizarragaDepartment of Pharmaceutical Technology and Chemistry, Research Group MITOX, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-0106-4930
Adela López de CerainDepartment of Pharmacology and Toxicology, Research Group MITOX, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-2085-1289
Elena González-PeñasDepartment of Pharmaceutical Technology and Chemistry, Research Group MITOX, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0003-1413-0829
Ariane VettorazziDepartment of Pharmacology and Toxicology, Research Group MITOX, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0001-9182-8417
Universidad de Navarra · ESCenter for Biomedical Research of La Rioja · ESHospital San Pedro · ESIstituto Superiore di Sanità · ITNavarre Institute of Health Research · ES

Funding

Departamento de Salud, Gobierno de Navarra Project-43, 2019 modality AMinisterio de Economía, Industria y Competitividad, Gobierno de España AGL2017-85732-R
6 · The paper itself

Abstract

Exposure to environmental contaminants might play an important role in neurodegenerative disease pathogenesis, such as Parkinson´s disease (PD) and Alzheimer´s disease (AD). For the first time in Spain, the plasmatic levels of 19 mycotoxins from patients diagnosed with a neurodegenerative disease (44 PD and 24 AD) and from their healthy companions (25) from La Rioja region were analyzed. The studied mycotoxins were aflatoxins B1, B2, G1, G2 and M1, T-2 and HT-2, ochratoxins A (OTA) and B (OTB), zearalenone, sterigmatocystin (STER), nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxy-deoxynivalenol, neosolaniol, diacetoxyscirpenol and fusarenon-X. Samples were analyzed by LC-MS/MS before and after treatment with β-glucuronidase/arylsulfatase in order to detect potential metabolites. Only OTA, OTB and STER were detected in the samples. OTA was present before (77% of the samples) and after (89%) the enzymatic treatment, while OTB was only detectable before (13%). Statistically significant differences in OTA between healthy companions and patients were observed but the observed differences might seem more related to gender (OTA levels higher in men,

Indexed as

Biological MonitoringAlzheimer DiseaseChromatography, LiquidHumansMycotoxinsNeurodegenerative DiseasesOchratoxinsParkinson DiseaseSterigmatocystinTandem Mass SpectrometryTrichothecenesZearalenone15-acetyldeoxynivalenol3-acetyldeoxynivalenoldiacetoxyscirpenolfusarenon-XMycotoxinsneosolaniolnivalenolochratoxin AOchratoxinsSterigmatocystinTrichothecenesZearalenoneAlzheimer´s diseasehuman exposuremycotoxinsneurodegenerative diseaseochratoxin AParkinson´s diseasesterigmatocystin

Identifiers

PMID34357949
PMCPMC8310068
OpenAlexW3179247944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.