Evidence map›Paper›PMID 34357794›Full record

ArticleThe British journal of radiology2021

Dosimetric analyses of intra-arterial versus standard intravenous administration of 177Lu-DOTATATE in patients of well differentiated neuroendocrine tumor with liver-dominant metastatic disease.

Parul Thakral, Ishita Sen, Subha Shankar Das, Divya Manda, Virupakshappa Cb, Dharmender Malik

Abstract read
In one paragraph

Article in The British journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Peptide Receptor Radionuclide Therapy.The Journal of clinical endocrinology and metabolism · 2022
    Article
  10. Role of Radioembolization in Metastatic Neuroendocrine Tumors.Cardiovascular and interventional radiology · 2022
    Review
  11. Article
  12. Intra-arterial PRRT with Lu-177 DOTATATE in Liver-dominant Metastatic Neuroendocrine Tumors: Early Assessment of Efficacy and Toxicity.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Parul ThakralDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Ishita SenDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Subha Shankar DasDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Divya MandaDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Virupakshappa CbDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.
Dharmender MalikDepartment of Nuclear Medicine, Fortis Memorial Research Institute, Gurgaon, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the present study was to perform calculation of the absorbed doses to organs at risk and to neuroendocrine tumors and to determine whether hepatic intra-arterial (IA) injection of

methods29 patients with Grade I-II, inoperable, metastatic gastro-entero-pancreatic neuroendocrine tumor (GEPNET) were prospectively identified and enrolled for the study. 15 patients of GEPNETs with liver-dominant metastatic disease and less than 3 sites of extrahepatic metastatic disease were administered a single dose of

resultsThe mean dose per unit activity (DpA) in the liver and tumor lesions in the IA group differed significantly (

conclusionIA administration of ADVANCES IN KNOWLEDGE: Measurement of the dose received by the tumor lesions and the critical organs is of paramount importance for the prognostication of a radionuclide therapy. Scant data exist on the dosimetric impact of IA administration of the therapy with

Indexed as

Administration, IntravenousAdultAgedCoordination ComplexesFemaleHumansInjections, Intra-ArterialLiver NeoplasmsMaleMiddle AgedNeoplasm GradingNeuroendocrine TumorsOctreotideOrganometallic CompoundsPilot ProjectsProspective Studies177Lu-DOTA-octreotateCoordination Complexeslutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticals

Identifiers

PMID34357794
PMCPMC9328058

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.