Evidence map›Paper›PMID 34357768›Full record

ArticleJournal of the American Chemical Society2021

Formulation of Metal-Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility.

Xu Chen, Yunhui Zhuang, Nakul Rampal, Rachel Hewitt, Giorgio Divitini, Christopher A O'Keefe, Xiewen Liu, Daniel J Whitaker, John W Wills, Ravin Jugdaohsingh and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 171 citations in OpenAlex.

  1. Review
  2. DNA-mimic for Specific Surface Functionalization of Zr-MOFs for Bacterial Targeting.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Metal-organic frameworks in pharmaceutical research.Pharmaceutical science advances · 2025
    Review
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  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Xu ChenThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0001-7793-036X
Yunhui ZhuangThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0001-8941-3749
Nakul RampalThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-6187-5631
Rachel HewittBiominerals Research Laboratory & Cellular Imaging and Analysis Facility, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom.ORCID 0000-0002-2367-1822
Giorgio DivitiniElectron Microscopy Group, Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 0FS, United Kingdom.ORCID 0000-0003-2775-610X
Christopher A O'KeefeDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.
Xiewen LiuThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-4864-1080
Daniel J WhitakerDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0001-7156-2519
John W WillsBiominerals Research Laboratory & Cellular Imaging and Analysis Facility, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom.ORCID 0000-0002-4347-5394
Ravin JugdaohsinghBiominerals Research Laboratory & Cellular Imaging and Analysis Facility, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom.
Jonathan J PowellBiominerals Research Laboratory & Cellular Imaging and Analysis Facility, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom.
Han YuSchool of Chemical and Environmental Engineering, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, P. R. China.ORCID 0000-0003-2565-8485
Clare P GreyDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0001-5572-192X
Oren A SchermanDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0001-8032-7166
David Fairen-JimenezThe Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical Engineering & Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.ORCID 0000-0002-5013-1194
University of Cambridge · GBShanghai Institute of Technology · CN

Funding

Medical Research Council MR/R005699/1
6 · The paper itself

Abstract

Metal-organic framework nanoparticles (nanoMOFs) have been widely studied in biomedical applications. Although substantial efforts have been devoted to the development of biocompatible approaches, the requirement of tedious synthetic steps, toxic reagents, and limitations on the shelf life of nanoparticles in solution are still significant barriers to their translation to clinical use. In this work, we propose a new postsynthetic modification of nanoMOFs with phosphate-functionalized methoxy polyethylene glycol (mPEG-PO

Indexed as

Cell SurvivalDoxorubicinDrug CarriersDrug LiberationHeLa CellsHumansMetal-Organic FrameworksMolecular Dynamics SimulationNanoparticlesPhosphatesPolyethylene GlycolsDoxorubicinDrug CarriersMetal-Organic FrameworksPhosphatesPolyethylene Glycols

Identifiers

PMID34357768
PMCPMC8414479
OpenAlexW3188677010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.