Evidence map›Paper›PMID 34357620›Full record

ArticleThe Veterinary record2021

Calcium oxalate urolithiasis in juvenile dogs.

Alexander Saver, Jody P Lulich, Samantha Van Buren, Eva Furrow

Open access · greenAbstract read
In one paragraph

Article in The Veterinary record, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Animals : an open access journal from MDPI · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alexander SaverDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0001-8431-8566
Jody P LulichDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.
Samantha Van BurenDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.ORCID https://orcid.org/0000-0003-1399-9637
Eva FurrowDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA.ORCID https://orcid.org/0000-0002-7339-2354
University of Minnesota · USUniversity of Wisconsin–Madison · US

Funding

The role of zinc transporters and dietary zinc in calcium oxalate urolithiasisK01OD019912 · OD · UNIVERSITY OF MINNESOTA · PI FURROW, EVA · 2015 to 2021
$760k
National Institute of Health ORIP K01 Mentored Research Scientist Development Award K01-OD019912NIH HHS K01 OD019912
6 · The paper itself

Abstract

backgroundThe features of juvenile-onset calcium oxalate urolithiasis in dogs have not been previously reported.

methodsCalcium oxalate urolith submissions to the Minnesota Urolith Center between 2012 and 2016 were analyzed to identify those originating from juvenile (≤2 years, n = 510) or mature (7-9 years, n = 39,093) dogs. Breed, sex, urolith salt type and urolith location were compared between groups. Breeds represented in both groups were also compared with respect to sex, urolith salt type and urolith location.

resultsFrench (odds ratios [OR] = 14.7, p < 0.001) and English (OR = 14.3, p < 0.001) Bulldogs were overrepresented in juvenile submissions. All juvenile French and English Bulldogs were male. Across all breeds, juvenile dogs were more likely to be male (89%, p < 0.001) than mature dogs (79%). Juvenile dogs were also more likely to form dihydrate stones compared to mature dogs (33% versus 14%, respectively; p < 0.001). Breed differences were discovered in sex, urolith salt type and stone location.

conclusionsFrench and English Bulldogs comprise a greater proportion of juvenile calcium oxalate urolith submissions than expected based on their rarity in mature submissions. Inherited risk factors, particularly X chromosome variants, should be investigated due to the strong breed and sex predispositions identified.

Indexed as

Age of OnsetAnimalsCalcium OxalateDog DiseasesDogsFemaleMaleRisk FactorsUrolithiasisCalcium Oxalatebulldoghyperuricosuriapaediatricpredispositionsurinary stones

Identifiers

PMID34357620
PMCPMC9159368
OpenAlexW3126705959

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.