ArticleMolecular biotechnology2021
Association of miR-192-5p with Atherosclerosis and its Effect on Proliferation and Migration of Vascular Smooth Muscle Cells.
Article in Molecular biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Harnessing miRNA therapeutics: a novel approach to combat heart and brain infarctions in atherosclerosis.Cell death discovery · 2025Review
- Predicting the ferroptosis-associated gene targets in atherosclerosis by integrating GWAS and eQTL studies summary data.Medicine · 2025Article
- Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis.International journal of molecular sciences · 2025Review
- Potential of miR-192-5p as a diagnostic marker for children with severe pneumonia and respiratory failure and its predictive value for prognosis.Central-European journal of immunology · 2025Article
- Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases.Communications biology · 2024Review
- Two sides of the same coin: Non-alcoholic fatty liver disease and atherosclerosis.Vascular pharmacology · 2024Review
- Hsa_circ_0032389 Enhances Proliferation and Migration in PDGF-BB-Induced Human Aortic Vascular Smooth Muscle Cells.Cardiovascular toxicology · 2024Article
- Exploration of ferroptosis and necroptosis-related genes and potential molecular mechanisms in psoriasis and atherosclerosis.Frontiers in immunology · 2024Article
- Hsa_ circ_0006867 regulates ox-LDL-induced endothelial injury via the miR-499a-3p/ADAM10 axis.Clinical hemorheology and microcirculation · 2024Article
- Tan IIA mitigates vascular smooth muscle cell proliferation and migration induced by ox-LDL through the miR-137/TRPC3 axis.The Kaohsiung journal of medical sciences · 2023Article
- MicroRNAs Regulate Function in Atherosclerosis and Clinical Implications.Oxidative medicine and cellular longevity · 2023Review
- Long non-coding RNA WAC antisense RNA 1 mediates hepatitis B virus replication <em>in vitro</em> by reinforcing miR-192-5p/ATG7-induced autophagy.European journal of histochemistry : EJH · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the diagnostic significance of serum miR-192-5p for atherosclerosis (AS) and explore the effect of miR-192-5p on cell proliferation and migration of vascular smooth muscle cells (VSMCs). The expression level of serum miR-192-5p was measured by qRT-PCR. Correlations of miR-192-5p with CRP and CIMT were evaluated by Pearson correlation coefficient. The diagnostic significance of miR-192-5p was assessed using an ROC curve. CCK-8 assay and Transwell assay were used to analyze the effect of miR-192-5p on cell proliferation and migration. Luciferase reporter gene assay was used to evaluate the effect of miR-192-5p with ATG7. The expression level of serum miR-192-5p in AS patients was significantly high compared with healthy controls. miR-192-5p was positively correlated with CRP and CIMT, and it has diagnostic value for AS. In vitro cell experiments confirmed that overexpression of miR-192-5p could promote cell proliferation and migration of VSMCs. miR-192-5p directly targets ATG7 in VSMCs. Down-regulation of miR-192-5p level increased ATG7 expression and inhibited cell proliferation and migration. miR-192-5p may be a new biomarker for the diagnosis of AS and may provide new idea for the treatment of AS.
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