Evidence map›Paper›PMID 34357487›Full record

ArticleMedical oncology (Northwood, London, England)2021

Combined evaluation of proliferation and apoptosis to calculate IC

Yeliz Ekici, Abdullah Yilmaz, Umut Can Kucuksezer, Sema Bilgic Gazioglu, Zeynep Dogusan Yamalioglu, Ali Osman Gurol, Thomas Linn, Feyza Nur Tuncer

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yeliz EkiciDepartment of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba Caddesi, Capa, 34093, Istanbul, Turkey.
Abdullah YilmazDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Umut Can KucuksezerDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Sema Bilgic GaziogluDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Zeynep Dogusan YamaliogluCell Processing Unit, Bone Marrow Transplantation Center, Yeni Yuzyil University Gaziosmanpasa Hospital, Istanbul, Turkey.
Ali Osman GurolDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Thomas LinnClinical Research Unit, Center of Internal Medicine, Justus-Liebig-University, Giessen, Germany.
Feyza Nur TuncerDepartment of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Vakif Gureba Caddesi, Capa, 34093, Istanbul, Turkey. ftuncer@istanbul.edu.tr.ORCID http://orcid.org/0000-0001-8233-1839
Istanbul University · TRBezmialem Foundation University Medical Faculty Hospital · TRIstanbul Yeni Yüzyıl University · TRJustus-Liebig-Universität Gießen · DE

Funding

Bilimsel Araştirma Projeleri Birimi, Istanbul Üniversitesi 32763
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most deadly cancers. Since most patients develop resistance to conventional treatments, new approaches are in urgency. Valproic acid (VPA) was shown to induce apoptosis and reduce proliferation in PANC-1 cells. Wnt signaling pathway is known to be involved in apoptosis and PDAC onset. However, VPA-induced apoptosis and its impact on Wnt signaling in PDACs are not linked, yet. We aimed to calculate IC

Indexed as

ApoptosisCell ProliferationAnticonvulsantsCarcinoma, Pancreatic DuctalGene Expression Regulation, NeoplasticHumansInhibitory Concentration 50Lymphoid Enhancer-Binding Factor 1Pancreatic NeoplasmsTumor Cells, CulturedValproic AcidWnt Signaling PathwayAnticonvulsantsLEF1 protein, humanLymphoid Enhancer-Binding Factor 1Valproic AcidApoptosisIC50Pancreatic ductal adenocarcinomaProliferationValproic acidWnt signaling

Identifiers

PMID34357487
OpenAlexW3192565417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.