Evidence map›Paper›PMID 34357470›Full record

ArticleInternational journal of clinical oncology2021

Effects of transurethral resection under general anesthesia on tumor recurrence in non-muscle invasive bladder cancer.

Yuto Baba, Eiji Kikuchi, Keisuke Shigeta, Koichiro Ogihara, Masashi Matsushima, Yui Nishimoto, Yasuaki Murata, Hirotaka Asakura, Masafumi Oyama, Ryuichi Mizuno and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Yuto BabaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Eiji KikuchiDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan. eiji-k@kb3.so-net.ne.jp.ORCID http://orcid.org/0000-0002-1624-6676
Keisuke ShigetaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Koichiro OgiharaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Masashi MatsushimaDepartment of Urology, Ogikubo Hospital, 3-1-24 Imagawa, Suginami, Tokyo, 167-0035, Japan.
Yui NishimotoDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Yasuaki MurataDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Hirotaka AsakuraDepartment of Urology, Saitama Medical University Hospital, 38 Morohongo Moroyama-machi, Iruma-gun, Saitama, 350-0495, Japan.
Masafumi OyamaDepartment of Uro-Oncology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka-shi, Saitama, 350-1298, Japan.
Ryuichi MizunoDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Mototsugu OyaDepartment of Urology, Keio University School of Medicine, 35 Shinanomachi, , Shinjuku, Tokyo, 160-8582, Japan.
Keio University · JPOgikubo Hospital · JPSaitama Medical University · JPSaitama Medical University Hospital · JPSt. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effects of the type of anesthesia (spinal (SA) vs. general (GA)) used for transurethral resection of bladder tumor (TURBT) on non-muscle invasive bladder cancer (NMIBC) recurrence and progression are controversial and our aim is to investigate their associations.

methodsWe identified 300 NMIBC patients who underwent initial TURBT with SA or GA. Cox's regression analysis was performed to examine the effects of anesthesia on tumor recurrence.

resultsAmong 300 patients, 153 (51.0%) received GA and 147 (49.0%) SA. The 5-year recurrence-free survival (RFS) rate was 59.9% in the GA group, which was significantly lower than that in the SA group (74.4%, p = 0.029). GA (HR 1.57, p = 0.048), male sex (HR 2.72, p = 0.012), and tumor multiplicity (HR 1.96, p = 0.006) were independently associated with tumor recurrence. In a subgroup of 137 patients with high-risk NMIBC, the 5-year RFS rate was 50.3% in the GA group, which was significantly lower than that in the SA group (77.6%, p = 0.020), and GA remained an independent indicator of tumor recurrence (HR 2.35, p = 0.016). However, no significant differences were observed in the RFS rates of low- to intermediate-risk NMIBC patients between the GA and SA groups.

conclusionsThe RFS rate was lower in NMIBC patients who received GA during TURBT than in those who received SA. Volatile anesthesia may increase tumor recurrence, particularly in high-risk NMIBC patients, which may be due to the inhibition of the immune response system during surgery.

Indexed as

Urinary Bladder NeoplasmsAnesthesia, GeneralCystectomyHumansMaleNeoplasm Recurrence, LocalGeneral anesthesiaNon-muscle invasive bladder cancerSpinal anesthesiaTransurethral resection of bladder tumorTumor recurrence

Identifiers

PMID34357470
OpenAlexW3192007869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.