Evidence map›Paper›PMID 34357416›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021

Characterizing temporal and spatial recruitment of systemically administered RPE65-programmed bone marrow-derived cells to the retina in a mouse model of age-related macular degeneration.

Carolina Francelin, Juliana Godoy, Xiaoping Qi, Juliete A F Silva, Maria B Grant, Michael E Boulton

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carolina Francelin *Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA. crovarotto@uabmc.edu.ORCID http://orcid.org/0000-0001-7439-3124
Juliana Godoy *Department of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA.ORCID http://orcid.org/0000-0003-1276-4297
Xiaoping QiDepartment of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA.
Juliete A F SilvaDepartment of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA.ORCID http://orcid.org/0000-0002-4543-5169
Maria B GrantDepartment of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA.
Michael E BoultonDepartment of Ophthalmology and Visual Sciences, University of Alabama At Birmingham, 1670 University Boulevard, Birmingham, AL, 35233, USA. meboulton@uabmc.edu.ORCID http://orcid.org/0000-0002-0796-1766
University of Alabama at Birmingham · USHospital Israelita Albert Einstein · BR

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
OPTIMIZING SYSTEMIC STEM/PROGENITOR CELL THERAPY FOR AMDR01EY023629 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOULTON, MICHAEL EDWIN, GRANT, MARIA BARTOLOMEO · 2013 to 2017
$2.7M
NEI NIH HHS P30 EY003039NEI NIH HHS P30 EY03039NEI NIH HHS R01 EY023629NIH HHS EY023629Research to Prevent Blindness Unrestricted grant to Dept
6 · The paper itself

Abstract

purposePreviously, we reported that the intravenous injection of bone marrow-derived cells (BMDC) infected with lentivirus expressing the human RPE65 gene resulted in the programming of BMDC to promote visual recovery in a mouse model of age-related macular degeneration (AMD). The aim of this study was to characterize the spatial and temporal recruitment of these programmed BMDC to the retinal pigment epithelial (RPE) layer.

methodsC57BL/6J female mice received a subretinal injection of AAV1-SOD2 ribozyme to knock down (KD) superoxide dismutase 2 (SOD2) and induce AMD-like pathology. BMDC were isolated from GFP

resultsGFP

conclusionsOur study shows that systemically administered GFP

Indexed as

Bone MarrowMacular DegenerationAnimalsFemaleLentivirusMiceMice, Inbred C57BLRetinaRetinal Pigment EpitheliumAge-related macular degenerationBone marrow-derived cellsCell recruitmentRetinal pigment epitheliumRPE65

Identifiers

PMID34357416
PMCPMC8478769
OpenAlexW3192306226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.