Evidence map›Paper›PMID 34357322›Full record

ArticleJournal of cardiovascular development and disease2021

Superimposed Tissue Formation in Human Aortic Valve Disease: Differences between Regurgitant and Stenotic Valves.

Boudewijn P T Kruithof, Aniek L van Wijngaarden, Babak Mousavi Gourabi, Jesper Hjortnaes, Meindert Palmen, Nina Ajmone Marsan

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Boudewijn P T KruithofDepartment of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0002-9604-4563
Aniek L van WijngaardenDepartment of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-5636-8945
Babak Mousavi GourabiDepartment of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Jesper HjortnaesDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Meindert PalmenDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Nina Ajmone MarsanDepartment of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.ORCID 0000-0001-7208-5769
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The formation of superimposed tissue (SIT), a layer on top of the original valve leaflet, has been described in patients with mitral regurgitation as a major contributor to valve thickening and possibly as a result of increased mechanical stresses. However, little is known whether SIT formation also occurs in aortic valve disease. We therefore performed histological analyses to assess SIT formation in aortic valve leaflets (

Indexed as

aortic regurgitationaortic stenosisfree edge foldingmyofibroblastsoriginal leafletsuperimposed tissue

Identifiers

PMID34357322
PMCPMC8306480
OpenAlexW3177744611

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.