Evidence map›Paper›PMID 34357186›Full record

ArticleMembranes2021

Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport.

Antonia Silvestri, Nicola Di Trani, Giancarlo Canavese, Paolo Motto Ros, Leonardo Iannucci, Sabrina Grassini, Yu Wang, Xuewu Liu, Danilo Demarchi, Alessandro Grattoni

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Space Medicines for Space Health.ACS medicinal chemistry letters · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Antonia SilvestriDepartment of Electronics and Telecommunications, Polytechnic of Turin, 10129 Turin, Italy.ORCID 0000-0001-6990-3521
Nicola Di TraniDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.ORCID 0000-0002-4780-7915
Giancarlo CanaveseDepartment of Applied Science and Technology, Polytechnic of Turin, 10129 Turin, Italy.
Paolo Motto RosDepartment of Electronics and Telecommunications, Polytechnic of Turin, 10129 Turin, Italy.ORCID 0000-0002-6955-3098
Leonardo IannucciDepartment of Applied Science and Technology, Polytechnic of Turin, 10129 Turin, Italy.ORCID 0000-0002-1996-1958
Sabrina GrassiniDepartment of Applied Science and Technology, Polytechnic of Turin, 10129 Turin, Italy.
Yu WangDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.ORCID 0000-0001-6053-896X
Xuewu LiuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.
Danilo DemarchiDepartment of Electronics and Telecommunications, Polytechnic of Turin, 10129 Turin, Italy.ORCID 0000-0001-5374-1679
Alessandro GrattoniDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA.ORCID 0000-0001-7888-422X
Houston Methodist · USPolitecnico di Torino · IT

Funding

A nanofluidic platform for tunable drug deliveryR01GM127558 · NIGMS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI GRATTONI, ALESSANDRO, LIU, XUEWU · 2018 to 2021
$1.6M
NIGMS NIH HHS R01GM127558
6 · The paper itself

Abstract

Manipulation of ions and molecules by external control at the nanoscale is highly relevant to biomedical applications. We report a biocompatible electrode-embedded nanofluidic channel membrane designed for electrofluidic applications such as ionic field-effect transistors for implantable drug-delivery systems. Our nanofluidic membrane includes a polysilicon electrode electrically isolated by amorphous silicon carbide (a-SiC). The nanochannel gating performance was experimentally investigated based on the current-voltage (I-V) characteristics, leakage current, and power consumption in potassium chloride (KCl) electrolyte. We observed significant modulation of ionic diffusive transport of both positively and negatively charged ions under physical confinement of nanochannels, with low power consumption. To study the physical mechanism associated with the gating performance, we performed electrochemical impedance spectroscopy. The results showed that the flat band voltage and density of states were significantly low. In light of its remarkable performance in terms of ionic modulation and low power consumption, this new biocompatible nanofluidic membrane could lead to a new class of silicon implantable nanofluidic systems for tunable drug delivery and personalized medicine.

Indexed as

electrical double layerionic modulation controlion rectificationnanofluidic channelnanofluidic ion transport

Identifiers

PMID34357186
PMCPMC8303522
OpenAlexW3180596137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.