Evidence map›Paper›PMID 34357147›Full record

ReviewJournal of personalized medicine2021

Parkinson's Disease: Personalized Pathway of Care for Device-Aided Therapies (DAT) and the Role of Continuous Objective Monitoring (COM) Using Wearable Sensors.

Vinod Metta, Lucia Batzu, Valentina Leta, Dhaval Trivedi, Aleksandra Powdleska, Kandadai Rukmini Mridula, Prashanth Kukle, Vinay Goyal, Rupam Borgohain, Guy Chung-Faye and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Vinod MettaDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
Lucia BatzuDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
Valentina LetaDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
Dhaval TrivediDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
Aleksandra PowdleskaDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
Kandadai Rukmini MridulaNizams Institute of Medical Sciences, Hyderabad 500082, India.
Prashanth KukleVikram Hospitals, Benguluru 560052, India.
Vinay GoyalMedanta Institute of Neurosciences, New Delhi 122001, India.
Rupam BorgohainNizams Institute of Medical Sciences, Hyderabad 500082, India.
Guy Chung-FayeDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
K Ray ChaudhuriDepartment of Neurosciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.
King's College Hospital · GBKing's College London · GBNizam's Institute of Medical Sciences · INMedanta The Medicity · INVikram Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a chronic, progressive neurological disorder and the second most common neurodegenerative condition. Advanced PD is complicated by erratic gastric absorption, delayed gastric emptying in turn causing medication overload, and hence the emergence of motor and non-motor fluctuations and dyskinesia, which is initially predictable and then becomes unpredictable. As the patient progresses to the advanced stage, advanced Parkinson's disease (APD) is characterized by refractory motor and non motor fluctuations, unpredictable OFF periods, and troublesome dyskinesias. The management of APD is a complex affair. There is growing recognition that GI dysfunction is common in PD, with virtually the entire GI system (the upper and lower GI tracts) causing problems from dribbling to defecation. The management of PD should focus on personalized care addressing both motor and non-motor symptoms, ideally including not only dopamine replacement but also associated non-dopaminergic circuits, particularly focusing on noradrenergic, serotonergic, and cholinergic therapies bypassing the gastrointestinal tract (GIT) by infusion or device-aided therapies (DAT), including levodopa-carbidopa intestinal gel infusion, apomorphine subcutaneous infusion, and deep brain stimulation, which are available in many countries for the management of the advanced stage of Parkinson's disease (APD). The PKG (KinetiGrap) can be used as a continuous objective monitoring (COM) aid, as a screening tool to help to identify advanced PD (APD) patients suitable for DAT, and can thus improve clinical outcomes.

Indexed as

advanced Parkinson’s disease (APD)apomorphine subcutaneous infusion therapyintrajejunallevodopamotor and non-motor symptomspainPKG (KinetiGrap)precision medicine

Identifiers

PMID34357147
PMCPMC8305099
OpenAlexW3186036431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.