Evidence map›Paper›PMID 34357130›Full record

ArticleJournal of personalized medicine2021

Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis.

Netanja I Harlianto, Jan Westerink, Wouter Foppen, Marjolein E Hol, Rianne Wittenberg, Pieternella H van der Veen, Bram van Ginneken, Jonneke S Kuperus, Jorrit-Jan Verlaan, Pim A de Jong and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

  1. The relation between cardiovascular calcifications and diffuse idiopathic skeletal hyperostosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  15. Systems Radiology and Personalized Medicine.Journal of personalized medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Netanja I HarliantoDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.ORCID 0000-0001-8196-3949
Jan WesterinkDepartment of Vascular Medicine, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Wouter FoppenDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.ORCID 0000-0003-4970-8555
Marjolein E HolDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Rianne WittenbergDepartment of Radiology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.ORCID 0000-0001-7828-374X
Pieternella H van der VeenDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Bram van GinnekenDepartment of Medical Imaging, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Jonneke S KuperusDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Jorrit-Jan VerlaanDepartment of Orthopedic Surgery, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Pim A de JongDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
Firdaus A A Mohamed HoeseinDepartment of Radiology, University Medical Center Utrecht and Utrecht University, 3584 CX Utrecht, The Netherlands.
On Behalf Of The Ucc-Smart-Study Group
Utrecht University · NLRadboud University Nijmegen · NLThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH.

methodsIn 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using

resultsDISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20-1.54) and females (OR: 1.43; 95%CI: 1.06-1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31-1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49-0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14-1.80).

conclusionMarkers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH.

Indexed as

adipositydiffuse idiopathic skeletal hyperostosisintra-abdominal fatrisk factors

Identifiers

PMID34357130
PMCPMC8305748
OpenAlexW3179934698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.