Evidence map›Paper›PMID 34357114›Full record

ArticleJournal of personalized medicine2021

Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network.

Nina R Sperber, Olivia M Dong, Megan C Roberts, Paul Dexter, Amanda R Elsey, Geoffrey S Ginsburg, Carol R Horowitz, Julie A Johnson, Kenneth D Levy, Henry Ong and 6 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Designing Software for Genomics Medicine Service Leaders to Engage Stakeholders.Proceedings. IEEE International Conference on Healthcare Informatics · 2023
    Article
  13. Precision Medicine in Type 1 Diabetes.Journal of the Indian Institute of Science · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nina R SperberDuke Department of Population Health Sciences, Duke University School of Medicine, Durham, NC 27701, USA.
Olivia M DongCenter for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.
Megan C RobertsDivision of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Paul DexterRegenstrief Institute, Indianapolis, Indiana University School of Medicine and Clem McDonald Center for Biomedical Informatics, Indianapolis, IN 46202, USA.
Amanda R ElseyCenter for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA.
Geoffrey S GinsburgCenter for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.
Carol R HorowitzInstitute for Health Equity Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Julie A JohnsonCenter for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA.
Kenneth D LevyDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 950 W. Walnut Street, Indianapolis, IN 46202, USA.
Henry OngDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Josh F PetersonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Toni I PollinDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Tejinder Rakhra-BurrisCenter for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.
Michelle A RamosDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Todd SkaarDivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 950 W. Walnut Street, Indianapolis, IN 46202, USA.
Lori A OrlandoCenter for Applied Genomics & Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA.ORCID 0000-0003-2534-7855

Funding

Genomic Diagnosis and Individualized Therapy of Highly Penetrant Genetic Diabetes (Administrative Supplment)U01HG007775 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI POLLIN, TONI I. · 2014 to 2018
$4.3M
Preparing Genetic Counselors for Genomic Medicine ResearchT32HG008955 · NHGRI · DUKE UNIVERSITY · PI COONEY, KATHLEEN A, HAGA, SUSANNE · 2017 to 2021
$2.0M
HSRD VA CIN 13-410NHGRI NIH HHS T32 HG008955NHGRI NIH HHS U01 HG007775NIH HHS U01 HG007269, UL1 TR 000064, U01 HG007253, U01 HG007762, U01 HG007282, U01 HG007775, U01 HG007278
6 · The paper itself

Abstract

The complexity of genomic medicine can be streamlined by implementing some form of clinical decision support (CDS) to guide clinicians in how to use and interpret personalized data; however, it is not yet clear which strategies are best suited for this purpose. In this study, we used implementation science to identify common strategies for applying provider-based CDS interventions across six genomic medicine clinical research projects funded by an NIH consortium. Each project's strategies were elicited via a structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC), and follow-up interviews guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, to obtain more detail about implementation strategies and desired outcomes. We found that, on average, the three pharmacogenomics implementation projects used more strategies than the disease-focused projects. Overall, projects had four implementation strategies in common; however, operationalization of each differed in accordance with each study's implementation outcomes. These four common strategies may be important for precision medicine program implementation, and pharmacogenomics may require more integration into clinical care. Understanding how and why these strategies were successfully employed could be useful for others implementing genomic or precision medicine programs in different contexts.

Indexed as

clinical decision supportgenomic medicineimplementation science

Identifiers

PMID34357114
PMCPMC8306482

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.