ReviewLife (Basel, Switzerland)2021
'Whole Organism', Systems Biology, and Top-Down Criteria for Evaluating Scenarios for the Origin of Life.
Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- Experimental evolution toward extinction in a molecular host-parasite system.Molecular biology and evolution · 2026Article
- Autocatalytic Selection as a Driver for the Origin of Life.Life (Basel, Switzerland) · 2024Article
- Opinion: The Key Steps in the Origin of Life to the Formation of the Eukaryotic Cell.Life (Basel, Switzerland) · 2024Review
- New Insights on the Origin of Life: The Role of Silico-Carbonates of Ba (II) to Preserve DNA against Highly Intense UV Radiation.ACS omega · 2023Article
- On the origin of life: an RNA-focused synthesis and narrative.RNA (New York, N.Y.) · 2023Article
- Article
- Novel Apparatuses for Incorporating Natural Selection Processes into Origins-of-Life Experiments to Produce Adaptively Evolving Chemical Ecosystems.Life (Basel, Switzerland) · 2022Article
- Potassium at the Origins of Life: Did Biology Emerge from Biotite in Micaceous Clay?Life (Basel, Switzerland) · 2022Article
- Prebiotic Chemistry: The Role of Trimetaphosphate in Prebiotic Chemical Evolution.Frontiers in chemistry · 2022Review
- Was There Land on the Early Earth?Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While most advances in the study of the origin of life on Earth (OoLoE) are piecemeal, tested against the laws of chemistry and physics, ultimately the goal is to develop an overall scenario for life's origin(s). However, the dimensionality of non-equilibrium chemical systems, from the range of possible boundary conditions and chemical interactions, renders the application of chemical and physical laws difficult. Here we outline a set of simple criteria for evaluating OoLoE scenarios. These include the need for containment, steady energy and material flows, and structured spatial heterogeneity from the outset. The Principle of Continuity, the fact that all life today was derived from first life, suggests favoring scenarios with fewer non-analog (not seen in life today) to analog (seen in life today) transitions in the inferred first biochemical pathways. Top-down data also indicate that a complex metabolism predated ribozymes and enzymes, and that full cellular autonomy and motility occurred post-LUCA. Using these criteria, we find the alkaline hydrothermal vent microchamber complex scenario with a late evolving exploitation of the natural occurring pH (or Na
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