Evidence map›Paper›PMID 34357061›Full record

ArticleLife (Basel, Switzerland)2021

Canine Lafora Disease: An Unstable Repeat Expansion Disorder.

Thilo von Klopmann, Saija Ahonen, Irene Espadas-Santiuste, Kaspar Matiasek, Daniel Sanchez-Masian, Stefan Rupp, Helene Vandenberghe, Jeremy Rose, Travis Wang, Peixiang Wang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Polyglucosan body disease in an aged chimpanzee (Pan troglodytes).Neuropathology : official journal of the Japanese Society of Neuropathology · 2023
    Article
  6. Article
  7. Lafora Disease and Alpha-Synucleinopathy in Two Adult Free-Ranging Moose (Animals : an open access journal from MDPI · 2022
    Article
  8. Review
  9. Dogs as a Natural Animal Model of Epilepsy.Frontiers in veterinary science · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Thilo von KlopmannDepartment of Neurology, Small Animal Clinic Hofheim, 65719 Hofheim, Germany.
Saija AhonenProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Irene Espadas-SantiusteInstitute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK.
Kaspar MatiasekSection of Clinical and Comparative Neuropathology, Ludwig-Maximilians-Universität München, 80539 München, Germany.
Daniel Sanchez-MasianInstitute of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston CH64 7TE, UK.ORCID 0000-0003-3851-0631
Stefan RuppDepartment of Neurology, Small Animal Clinic Hofheim, 65719 Hofheim, Germany.
Helene VandenbergheHighcroft Veterinary Referrals, Whitchurch, Bristol BS14 9BE, UK.
Jeremy RoseLumbry Park Veterinary Specialists, Alton GU34 3HL, UK.
Travis WangProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Peixiang WangProgram in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Berge Arakel MinassianDivision of Neurology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75201, USA.
Clare RusbridgeSchool of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0000-0002-3366-2110
Hospital for Sick Children · CAUniversity of Liverpool · GBLudwig-Maximilians-Universität München · DEThe University of Texas Southwestern Medical Center · USUlverscroft (United Kingdom) · GBUniversity of Surrey · GBWillows Veterinary Centre and Referral Service · GB

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
6 · The paper itself

Abstract

Canine Lafora disease is a recessively inherited, rapidly progressing neurodegenerative disease caused by the accumulation of abnormally constructed insoluble glycogen Lafora bodies in the brain and other tissues due to the loss of NHL repeat containing E3 ubiquitin protein ligase 1 (

Indexed as

canineChihuahuadodecamer repeat mutationEPM2AFrench BulldogGriffon Bruxelloishypnic jerkmuscle biopsyNHLRC1photoconvulsionsprogressive myoclonic epilepsy

Identifiers

PMID34357061
PMCPMC8304204
OpenAlexW3180501416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.