Evidence map›Paper›PMID 34357048›Full record

ReviewLife (Basel, Switzerland)2021

Liquid Biopsy and Potential Liquid Biopsy-Based Biomarkers in Philadelphia-Negative Classical Myeloproliferative Neoplasms: A Systematic Review.

Mihnea-Alexandru Găman, Matei-Alexandru Cozma, Elena-Codruța Dobrică, Sanda Maria Crețoiu, Amelia Maria Găman, Camelia Cristina Diaconu

Open access · goldAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  18. Biomolecules · 2022
    Review
  19. JAK2 in Myeloproliferative Neoplasms: Still a Protagonist.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mihnea-Alexandru GămanFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-7133-8875
Matei-Alexandru CozmaDepartment of Gastroenterology, Colentina Clinical Hospital, 020125 Bucharest, Romania.ORCID 0000-0002-4998-0105
Elena-Codruța DobricăDepartment of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Sanda Maria CrețoiuDepartment of Cell and Molecular Biology and Histology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-2575-4880
Amelia Maria GămanDepartment of Pathophysiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0001-6974-2772
Camelia Cristina DiaconuFaculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0001-6837-260X
Carol Davila University of Medicine and Pharmacy · ROClinical Emergency Hospital Bucharest · ROSpitalul Clinic Colentina · ROUniversity of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myeloproliferative neoplasms (MPNs) are rare, clonal disorders of the hematopoietic stem cell in which an uncontrolled proliferation of terminally differentiated myeloid cells is noted. Polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) are included in the category of Philadelphia-negative, so-called classical MPNs. The potential applications of liquid biopsy and liquid biopsy-based biomarkers have not been explored in MPNs until now. Thus, a systematic search was computed in PubMed/MEDLINE, Web of Science and The Cochrane Library and, in total, 198 potentially relevant papers were detected. Following the removal of duplicates (

Indexed as

cell-free DNAcirculating endothelial cellsessential thrombocythemiaextracellular vesiclesliquid biopsymicroparticlesmicrovesiclesmyeloproliferative neoplasmspolycythemia veraprimary myelofibrosis

Identifiers

PMID34357048
PMCPMC8304270
OpenAlexW3181045831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.