Evidence map›Paper›PMID 34357037›Full record

ReviewLife (Basel, Switzerland)2021

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies.

Lucas Fernando Sérgio Gushiken, Fernando Pereira Beserra, Jairo Kenupp Bastos, Christopher John Jackson, Cláudia Helena Pellizzon

Registry-linked trialAbstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05471180 (Adjuvant Effect of Photobiomodulation in the Treatment of Incontinence-associated Dermatitis in Adults - a Randomized Controlled Clinical Trial), which is not on this map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05471180 nawithdrawnnot on this mapstarted 2022, after this paper: background citation

Adjuvant Effect of Photobiomodulation in the Treatment of Incontinence-associated Dermatitis in Adults - a Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2022 to 2023Enrolled0ConditionsIncontinence Associated Dermatitis, Diaper Rash, Photobiomodulation TherapyArmsprotective spray film, photobiomodulation therapy
3 · Its place in the literature

Who cites it

119 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Negative Pressure Wound Therapy Modulates Wound pH and Bacterial Invasion inPlastic and reconstructive surgery. Global open · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucas Fernando Sérgio GushikenInstitute of Biosciences of Botucatu, São Paulo State University-UNESP, São Paulo 18618-689, Brazil.ORCID 0000-0001-9143-3706
Fernando Pereira BeserraSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, São Paulo 18618-689, Brazil.ORCID 0000-0002-0498-4444
Jairo Kenupp BastosSchool of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo-USP, São Paulo 18618-689, Brazil.
Christopher John JacksonKolling Institute of Medical Research, The University of Sydney at Royal North Shore Hospital, St. Leonard, Sydney 2065, Australia.ORCID 0000-0002-7177-1203
Cláudia Helena PellizzonInstitute of Biosciences of Botucatu, São Paulo State University-UNESP, São Paulo 18618-689, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/04138-8
6 · The paper itself

Abstract

The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.

Indexed as

dressingsskinskin substitutestopical formulationwound healingwound therapies

Identifiers

PMID34357037
PMCPMC8307436

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.