ReviewAntibiotics (Basel, Switzerland)2021
Antimicrobial Activity of Calcium Silicate-Based Dental Materials: A Literature Review.
Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Comparative Analysis of the Physical Properties of Three Different Tricalcium Silicate Cements: An In Vitro Study.European journal of dentistry · 2026Article
- Comprehensive evaluation of antibacterial activity, pH stability, and surface characterization of a mussel-inspired polymer for root perforation repair.Frontiers in dental medicine · 2026Article
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
- Biomaterials in Restorative Dentistry and Endodontics.Journal of functional biomaterials · 2025Article
- Article
- Antibacterial effects of bioactive restorative dental materials on Streptococcus mutans: An in vitro study using the direct contact test.The Saudi dental journal · 2025Article
- [Defect modification of calcium silicate and its application in oral bacteriostasis and tooth remineralization].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- Bioceramics in Endodontics: Limitations and Future Innovations-A Review.Dentistry journal · 2025Review
- Physicochemical and Antimicrobial Properties of Bioceramic Sealer Enhanced with Silver Nanoparticles: An in vitro Evaluation.Clinical, cosmetic and investigational dentistry · 2025Article
- Effect of Vital Pulp Therapy Biomaterials on Tooth Discolouration: A Review of the Literature.International journal of biomaterials · 2025Review
- Antibiofilm efficacy of a calcium silicate-based intracanal medicament against Fusobacterium nucleatum strains.Scientific reports · 2024Article
- Mechanical and Physicochemical Characteristics of a Novel Premixed Calcium Silicate Sealer.Materials (Basel, Switzerland) · 2024Article
- Nanostructured Glass-Ceramic Materials from Glass Waste with Antimicrobial Activity.Molecules (Basel, Switzerland) · 2024Article
- Transforming Natural Eggshell and Diatomite into Bioactive Calcium Silicate Material for Bone Regeneration.ACS omega · 2024Article
- Zinc and Silver-Infused Calcium Silicate Cement: Unveiling Physicochemical Properties and In Vitro Biocompatibility.Cureus · 2023Article
- Investigation on the physical properties and biocompatibility of zirconia-alumina-silicate@diopside composite materials and itsRSC advances · 2023Article
- Evaluating the efficacy of endodontic microsurgery for teeth with an undeveloped root apex and periapical periodontitis after nonsurgical treatment failure.BMC oral health · 2023Article
- Fast-Setting Calcium Silicate-Based Pulp Capping Cements-Integrated Antibacterial, Irritation and Cytocompatibility Assessment.Materials (Basel, Switzerland) · 2023Article
- Sol-gel synthesis of lithium doped mesoporous bioactive glass nanoparticles and tricalcium silicate for restorative dentistry: Comparative investigation of physico-chemical structure, antibacterial susceptibility and biocompatibility.Frontiers in bioengineering and biotechnology · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Endodontic biomaterials have significantly improved dental treatment techniques in several aspects now that they can be used for vital pulp treatments, as temporary intracanal medication, in definitive fillings, in apical surgeries, and for regenerative procedures. Calcium silicate-based cement is a class of dental material that is used in endodontics in direct contact with the dental structures, connective tissue, and bone. Because the material interacts with biological tissues and stimulates biomineralization processes, its properties are of major importance. The main challenge in endodontic treatments is the elimination of biofilms that are present in the root canal system anatomical complexities, as it remains even after chemical-mechanical preparation and disinfection procedures. Thus, an additional challenge for these biomaterials is to exert antimicrobial activity while maintaining their biological properties in parallel. This article reviews the literature for studies considering the antimicrobial properties of calcium silicate-based dental biomaterials used in endodontic practice. Considering the reviewed studies, it can be affirmed that the reduced antimicrobial effect exhibited by calcium silicate-based endodontic materials clearly emphasizes that all clinical procedures prior to their use must be carefully performed. Future studies for the evaluation of these materials, and especially newly proposed materials, under poly-microbial biofilms associated with endodontic diseases will be necessary.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.