ArticleAntibiotics (Basel, Switzerland)2021
Bacterial Natural Product Drug Discovery for New Antibiotics: Strategies for Tackling the Problem of Antibiotic Resistance by Efficient Bioprospecting.
Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Strepactones A-C: Unprecedented 6/8/5-Tricyclic Polyketides and Their Derivative from a Coral Reef-DerivedMarine drugs · 2026Article
- Silver-based N-heterocyclic carbene (NHC) complexes as emerging strategies against antimicrobial resistance.Archives of microbiology · 2026Review
- Natural Products and Antimicrobial Nanoparticles Against Methicillin-ResistantPharmaceutics · 2026Review
- Screening of 44 Baltic Sea Cyanobacterial Strains for Antibacterial and Quorum Sensing Inhibitory Potential: Selection of Promising Candidates.Antibiotics (Basel, Switzerland) · 2026Article
- Revealing actinobacterial diversity inhabiting Malaysian Beach Ridges Interspersed with Swales (BRIS) soil : insights from culture-dependent and metagenomic approaches.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Amazonian Fungal Diversity and the Potential of Basidiomycetes as Sources of Novel Antimicrobials.Biology · 2026Review
- Natural Products as Potentiators of β-Lactam Antibiotics: A Review of Mechanisms, Advances, and Future Directions.Antioxidants (Basel, Switzerland) · 2026Review
- Decoding the regulatory role of AmiC in amicoumacins production through transcriptomics and metabolic profiling in Bacillus subtilis fmb60.World journal of microbiology & biotechnology · 2026Article
- Molecular life sciences in the era of the Fourth Industrial Revolution: sequencing, multi-omics and artificial intelligence.Emerging topics in life sciences · 2025Review
- Emerging Multimodal Strategies for Bacterial Biofilm Eradication: A Comprehensive Review.Microorganisms · 2025Review
- Assessing the effect of temperature onMicrobiology (Reading, England) · 2025Article
- Unveiling the Chemical Composition, Enantiomeric Profile, Antibacterial, Anticholinesterase and Antioxidant Activity of the Essential Oil ofMolecules (Basel, Switzerland) · 2025Article
- Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis.Nature chemistry · 2025Article
- Microbial secondary metabolites: advancements to accelerate discovery towards application.Nature reviews. Microbiology · 2025Review
- Antimicrobial activities and beta-lactamase inhibitory property of actinomycetes from Atlas forest soils in Northeastern Algeria.World journal of microbiology & biotechnology · 2025Article
- Reviving the past for a healthier future: ancient molecules and remedies as a solution to the antibiotic crisis.Future microbiology · 2025Review
- Isolation of antibiotic-resistant strains ofJournal of advanced veterinary and animal research · 2025Article
- Bioactive potency of extracts fromBiomedical reports · 2025Article
- Effects of Prolonged Antibiotic Therapy in Lung Abscesses-Analysis of Case Series.Case reports in pulmonology · 2025Article
- Bioprospecting secondary metabolites with antimicrobial properties from soil bacteria in high-temperature ecosystems.Microbial cell factories · 2024Article
Corrections and comments
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Authors and funding
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Funding
Abstract
The problem of antibiotic resistance has become a challenge for our public health and society; it has allowed infectious diseases to re-emerge as a risk to human health. New antibiotics that are introduced to the market face the rise of resistant pathogens after a certain period of use. The relatively fast development of resistance against some antibiotics seems to be closely linked to their microbial origin and function in nature. Antibiotics in clinical use are merely products of microorganisms or derivatives of microbial products. The evolution of these antimicrobial compounds has progressed with the evolution of the respective resistance mechanisms in microbes for billions of years. Thus, antimicrobial resistance genes are present within the environment and can be taken up by pathogens through horizontal gene transfer. Natural products from bacteria are an important source of leads for drug development, and microbial natural products have contributed the most antibiotics in current clinical use. Bioprospecting for new antibiotics is a labor-intensive task as obstacles such as redetection of known compounds and low compound yields consume significant resources. The number of bacterial isolates one can theoretically investigate for new secondary metabolites is, on the other hand, immense. Therefore, the available capacity for biodiscovery should be focused on the most promising sources for chemical novelty and bioactivity, employing the appropriate scientific tools. This can be done by first looking into under- or unexplored environments for bacterial isolates and by focusing on the promising candidates to reduce the number of subjects.
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