Performance Comparison of Flow-Through Optofluidic Biosensor Designs.

Joel G Wright, Md Nafiz Amin, Holger Schmidt, Aaron R Hawkins

Abstract read

In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Comparison of Illumination Methods for Flow-Through Optofluidic Biosensors.Micromachines · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joel G WrightElectrical and Computer Engineering, Brigham Young University, 450 Engineering Building, Provo, UT 84602, USA.ORCID 0000-0002-2532-4429

Md Nafiz AminElectrical and Computer Engineering, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.

Holger SchmidtElectrical and Computer Engineering, University of California, 1156 High Street, Santa Cruz, CA 95064, USA.

Aaron R HawkinsElectrical and Computer Engineering, Brigham Young University, 450 Engineering Building, Provo, UT 84602, USA.

Funding

Multiplexed, Non-Amplified, Nucleic Acid-Based Identification of Multidrug Resistant Pathogens Using an Integrated Optofluidic PlatformR01AI116989 · NIAID · BRIGHAM YOUNG UNIVERSITY · PI HAWKINS, AARON R., PITT, WILLIAM G · 2015 to 2019

$5.4M

NIAID NIH HHS R01 AI116989NIH HHS 1R01AI116989NIH HHS 5R01EB028608

6 · The paper itself

Abstract

Optofluidic flow-through biosensors are being developed for single particle detection, particularly as a tool for pathogen diagnosis. The sensitivity of the biosensor chip depends on design parameters, illumination format (side vs. top), and flow configuration (parabolic, two- and three-dimensional hydrodynamic focused (2DHF and 3DHF)). We study the signal differences between various combinations of these design aspects. Our model is validated against a sample of physical devices. We find that side-illumination with 3DHF produces the strongest and consistent signal, but parabolic flow devices process a sample volume more quickly. Practical matters of optical alignment are also discussed, which may affect design choice.

Indexed as

Lab-On-A-Chip DevicesBiosensing TechniquesHydrodynamicsMicrofluidic Analytical Techniquesbiosensorfluorescencehydrodynamic focusinglab-on-a-chipliquid-core waveguideoptofluidic

Identifiers

PMID34356697

DOI10.3390/bios11070226

PMCPMC8301811

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.