Evidence map›Paper›PMID 34356682›Full record

ReviewBiomolecules2021

Oligodendrocytes and Microglia: Key Players in Myelin Development, Damage and Repair.

Ilias Kalafatakis, Domna Karagogeos

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ilias KalafatakisLaboratory of Neuroscience, Department of Basic Science, University of Crete Medical School, 70013 Heraklion, Greece.ORCID 0000-0002-7520-3158
Domna KaragogeosLaboratory of Neuroscience, Department of Basic Science, University of Crete Medical School, 70013 Heraklion, Greece.

Funding

Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques Τ2ΕΔΚ-00501
6 · The paper itself

Abstract

Oligodendrocytes, the myelin-making cells of the CNS, regulate the complex process of myelination under physiological and pathological conditions, significantly aided by other glial cell types such as microglia, the brain-resident, macrophage-like innate immune cells. In this review, we summarize how oligodendrocytes orchestrate myelination, and especially myelin repair after damage, and present novel aspects of oligodendroglial functions. We emphasize the contribution of microglia in the generation and regeneration of myelin by discussing their beneficial and detrimental roles, especially in remyelination, underlining the cellular and molecular components involved. Finally, we present recent findings towards human stem cell-derived preclinical models for the study of microglia in human pathologies and on the role of microbiome on glial cell functions.

Indexed as

AnimalsDemyelinating DiseasesHumansMicrobiotaMicrogliaMyelin SheathOligodendrogliaRegenerationRemyelinationStem Cellsdemyelinationinflammationmicrogliamultiple sclerosismyelinoligodendrocytesremyelination

Identifiers

PMID34356682
PMCPMC8301746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.