Evidence map›Paper›PMID 34356652›Full record

ReviewBiomolecules2021

Prevention of Post-Operative Adhesions: A Comprehensive Review of Present and Emerging Strategies.

Ali Fatehi Hassanabad, Anna N Zarzycki, Kristina Jeon, Jameson A Dundas, Vishnu Vasanthan, Justin F Deniset, Paul W M Fedak

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06315582 (Surgical Approach to Uterine Septum), which is not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
18.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06315582 narecruitingnot on this mapstarted 2024, after this paper: background citation

Surgical Approach to Uterine Septum: A Randomized Controlled Trial

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2026Enrolled40ConditionsUterine Septum, Surgical Complication, Septum, UterusArmsRemoval of uterine septum with hysteroscopic scissors without electrosurgery., Hysteroscopic septoplasty utilizing bipolar electrosurgery
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Diagnostic Accuracy of Transvaginal Ultrasound for Detecting Pelvic Adhesions and Predicting Surgical Time in Benign Gynecologic Surgery.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. The Effect of TISSEELMedicina (Kaunas, Lithuania) · 2026
    Article
  11. Article
  12. Review
  13. L-Glutamine attenuates peritoneal fibrosis developed in 5-Fluorouracil-treated mice.Experimental biology and medicine (Maywood, N.J.) · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. A Developmental Roadmap Toward Abdominal Adhesions Prevention Technologies.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ali Fatehi HassanabadSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.
Anna N ZarzyckiSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.ORCID 0000-0003-4178-692X
Kristina JeonDepartment of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, Canada.
Jameson A DundasSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.
Vishnu VasanthanSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.
Justin F DenisetSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.
Paul W M FedakSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, Canada.ORCID 0000-0003-0658-9381
University of Calgary · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-operative adhesions affect patients undergoing all types of surgeries. They are associated with serious complications, including higher risk of morbidity and mortality. Given increased hospitalization, longer operative times, and longer length of hospital stay, post-surgical adhesions also pose a great financial burden. Although our knowledge of some of the underlying mechanisms driving adhesion formation has significantly improved over the past two decades, literature has yet to fully explain the pathogenesis and etiology of post-surgical adhesions. As a result, finding an ideal preventative strategy and leveraging appropriate tissue engineering strategies has proven to be difficult. Different products have been developed and enjoyed various levels of success along the translational tissue engineering research spectrum, but their clinical translation has been limited. Herein, we comprehensively review the agents and products that have been developed to mitigate post-operative adhesion formation. We also assess emerging strategies that aid in facilitating precision and personalized medicine to improve outcomes for patients and our healthcare system.

Indexed as

AcetylcysteineAnti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsGenetic TherapyHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaterials TestingMolecular Targeted TherapyNanoparticlesPolymersPostoperative ComplicationsReceptors, AngiotensinSurgical MeshTissue AdhesionsAcetylcysteineAnti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsHydroxymethylglutaryl-CoA Reductase InhibitorsPolymersReceptors, Angiotensinbarriersbiomaterialsimmune mediatorspharmaceuticalspost-surgical adhesions

Identifiers

PMID34356652
PMCPMC8301806
OpenAlexW3177926842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.