Evidence map›Paper›PMID 34356648›Full record

ArticleBiomolecules2021

The Analysis of NADPH Quinone Reductase 1 (NQO1) Polymorphism in Polish Patients with Colorectal Cancer.

Jarosław Gorący, Anna Bogacz, Izabela Uzar, Marlena Wolek, Małgorzata Łochyńska, Paweł Ziętek, Bogusław Czerny, Aneta Cymbaluk-Płoska, Piotr Modliborski, Adam Kamiński

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jarosław GorącyIndependent Laboratory of Invasive Cardiology, Faculty of Medicine and Dentistry Pomeranian Medical University, 70-111 Szczecin, Poland.
Anna BogaczDepartment of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, 62-064 Plewiska, Poland.ORCID 0000-0001-5455-8315
Izabela UzarDepartment of Pharmacology and Pharmacoeconomics, Faculty of Health Sciences, Pomeranian Medical University, 71-230 Szczecin, Poland.
Marlena WolekDepartment of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, 62-064 Plewiska, Poland.
Małgorzata ŁochyńskaInstitute of Natural Fibres and Medicinal Plants, 60-630 Poznań, Poland.
Paweł ZiętekDepartment of Orthopedics, Traumatology and Orthopedic Oncology, Faculty of Medicine and Dentistry, Pomeranian Medical University, 71-252 Szczecin, Poland.
Bogusław CzernyDepartment of Pharmacology and Pharmacoeconomics, Faculty of Health Sciences, Pomeranian Medical University, 71-230 Szczecin, Poland.
Aneta Cymbaluk-PłoskaDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Faculty of Medicine and Dentistry, Pomeranian Medical University, 70-111 Szczecin, Poland.
Piotr ModliborskiDepartment of Orthopedics and Traumatology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University, 71-252 Szczecin, Poland.
Adam KamińskiDepartment of Orthopedics and Traumatology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University, 71-252 Szczecin, Poland.
Pomeranian Medical University · PLInstitute of Natural Fibres and Medicinal Plants · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the most common malignancies in Poland. Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. It is an enzyme which is a part of the body's antioxidant defense system. The aim of the study was to evaluate the correlation between the 609C > T polymorphism of the NQO1 gene and colorectal cancer risk in the Polish population. A total of 512 people were recruited for the study, including 279 patients with colorectal cancer, diagnosed at the University Hospital, Pomeranian Medical University in Szczecin. Genomic DNA was isolated from peripheral blood and the analyzed polymorphism was determined by PCR-RFLP. In the present study, we analyzed the clinical valuesand frequency of NQO1 609C > T polymorphism in patients diagnosed with colorectal cancer and controls. In case of the carriers of the TT genotype of the NQO1 polymorphism, an elevated risk for colorectal cancer was observed (OR = 2.96; 95% CI: 1.02-10.40). The analysis of the clinical parameters concerning the location and characteristics of the tumor stage revealed a statistically significant increase in the risk for colorectal cancer in the carriers of the TT genotype of the NQO1 polymorphism.

Indexed as

Polymorphism, GeneticAgedCase-Control StudiesColorectal NeoplasmsFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMaleMiddle AgedNAD(P)H Dehydrogenase (Quinone)PolandNAD(P)H Dehydrogenase (Quinone)NQO1 protein, humancolorectal cancergene polymorphismNQO1polymerase chain reaction

Identifiers

PMID34356648
PMCPMC8301863
OpenAlexW3181813986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.