Evidence map›Paper›PMID 34356643›Full record

ReviewBiomolecules2021

TRPV Protein Family-From Mechanosensing to Cancer Invasion.

Tytti Kärki, Sari Tojkander

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Calcium channels as pharmacological targets for cancer therapy.Clinical and experimental medicine · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Bioelectricity in dental medicine: a narrative review.Biomedical engineering online · 2024
    Review
  18. Article
  19. Article
  20. Challenges and Future Trends in Atopic Dermatitis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Tytti KärkiDepartment of Applied Physics, School of Science, Aalto University, 00076 Espoo, Finland.
Sari TojkanderDepartment of Veterinary Biosciences, Section of Pathology, University of Helsinki, 00014 Helsinki, Finland.
Aalto University · FIUniversity of Helsinki · FI

Funding

Academy of Finland 1332258
6 · The paper itself

Abstract

Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive intracellular signaling pathways through spatio-temporally controlled Ca

Indexed as

Epithelial-Mesenchymal TransitionHumansMechanotransduction, CellularNeoplasmsNeovascularization, Pathologicrho GTP-Binding ProteinsTRPV Cation Channelsrho GTP-Binding ProteinsTRPV Cation ChannelscancerinvasionmechanosensingTRPV

Identifiers

PMID34356643
PMCPMC8301805
OpenAlexW3181712360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.