Evidence map›Paper›PMID 34356627›Full record

ArticleBiomolecules2021

The Influence of Bloom Index, Endotoxin Levels and Polyethylene Glycol Succinimidyl Glutarate Crosslinking on the Physicochemical and Biological Properties of Gelatin Biomaterials.

Zhuning Wu, Stefanie H Korntner, Jos Olijve, Anne Maria Mullen, Dimitios I Zeugolis

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Zhuning WuRegenerative, Modular & Developmental Engineering Laboratory (REMODEL) and Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway (NUI Galway), H91 TK33 Galway, Ireland.
Stefanie H KorntnerRegenerative, Modular & Developmental Engineering Laboratory (REMODEL) and Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway (NUI Galway), H91 TK33 Galway, Ireland.
Jos OlijveRousselot BV, 9000 Gent, Belgium.
Anne Maria MullenTeagasc Food Research Centre, Ashtown, D15 DY05 Dublin, Ireland.ORCID 0000-0003-1769-0768
Dimitios I ZeugolisRegenerative, Modular & Developmental Engineering Laboratory (REMODEL) and Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM), National University of Ireland Galway (NUI Galway), H91 TK33 Galway, Ireland.ORCID 0000-0002-7599-5191
Science Foundation Ireland · IETeagasc - The Irish Agriculture and Food Development Authority · IEUniversity College Dublin · IE

Funding

H2020 European Research Council 866126Science Foundation Ireland (SFI) 15/CDA/3629, 19/FFP/6982, 13/RC/2073_2Teagasc 2014045, 11/F/043
6 · The paper itself

Abstract

In the medical device sector, bloom index and residual endotoxins should be controlled, as they are crucial regulators of the device's physicochemical and biological properties. It is also imperative to identify a suitable crosslinking method to increase mechanical integrity, without jeopardising cellular functions of gelatin-based devices. Herein, gelatin preparations with variable bloom index and endotoxin levels were used to fabricate non-crosslinked and polyethylene glycol succinimidyl glutarate crosslinked gelatin scaffolds, the physicochemical and biological properties of which were subsequently assessed. Gelatin preparations with low bloom index resulted in hydrogels with significantly (

Indexed as

Biocompatible MaterialsCross-Linking ReagentsElastic ModulusEndotoxinsGelatinHumansHydrogelsPolyethylene GlycolsTHP-1 CellsBiocompatible MaterialsCross-Linking ReagentsEndotoxinsGelatinHydrogelsPolyethylene Glycolsbloom indexendotoxin levelsgelatin biomaterialsmacrophage response

Identifiers

PMID34356627
PMCPMC8301829
OpenAlexW3180943337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.