Evidence map›Paper›PMID 34356574›Full record

ArticleChildren (Basel, Switzerland)2021

Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary Hypertension.

Amy L Lesneski, Payam Vali, Morgan E Hardie, Satyan Lakshminrusimha, Deepika Sankaran

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07322133 (Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07322133 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Dopamine vs. Norepinephrine in Term and Late Preterm Neonates With Hypoxemic Respiratory Failure and Systemic Hypotension Due to Pulmonary Hypertension: A Pilot Trial

TypeinterventionalSponsorUniversity of California, DavisRan2026 to 2027Enrolled30ConditionsHypotension and Shock, Pulmonary Hypertension of the Newborn (PPHN), Hypoxemic Respiratory FailureArmsDopamine administration, Norepinephrine
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Stabilization and Resuscitation of Newborns.Children (Basel, Switzerland) · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amy L LesneskiDepartment of Stem Cell Research, University of California, Davis, Sacramento, CA 95817, USA.
Payam ValiDepartment of Pediatrics, University of California, Davis, Sacramento, CA 95817, USA.
Morgan E HardieDepartment of Pediatrics, University of California, Davis, Sacramento, CA 95817, USA.
Satyan LakshminrusimhaDepartment of Pediatrics, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-6098-2155
Deepika SankaranDepartment of Pediatrics, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-6704-6949
University of California, Davis · US

Funding

Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01 HD072929
6 · The paper itself

Abstract

Neonatal resuscitation (NRP) guidelines suggest targeting 85-95% preductal SpO

Indexed as

asphyxiaductus arteriosusmeconium aspirationneonatal resuscitationoxygen saturation targetspersistent pulmonary hypertension of the newbornpost-resuscitationpulmonary blood flow

Identifiers

PMID34356574
PMCPMC8305411
OpenAlexW3181372445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.