Evidence map›Paper›PMID 34356519›Full record

ArticleBiology2021

Downregulation of Ribosomal Contents and Kinase Activities Is Associated with the Inhibitive Effect on the Growth of Group B Streptococcus Induced by Placental Extracellular Vesicles.

Jing Gao, Yunhui Tang, Xinyi Sun, Qiujing Chen, Yiqian Peng, Catherine Jia-Yun Tsai, Qi Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jing GaoDepartment of Medical Laboratory, The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai 200081, China.
Yunhui TangDepartment of Family Planning, The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai 200081, China.
Xinyi SunDepartment of Obstetrics & Gynaecology, The University of Auckland, Auckland 1142, New Zealand.
Qiujing ChenInstitute of Cardiovascular Disease, Ruijing Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200081, China.
Yiqian PengDepartment of Medical Laboratory, The Hospital of Obstetrics & Gynaecology, Fudan University, Shanghai 200081, China.
Catherine Jia-Yun TsaiDepartment of Molecular Medicine and Pathology, The University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-8365-5552
Qi ChenDepartment of Obstetrics & Gynaecology, The University of Auckland, Auckland 1142, New Zealand.ORCID 0000-0001-5894-6331
University of Auckland · NZObstetrics and Gynecology Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLike many other cell types, the human placenta produces large amounts of extracellular vesicles (EVs). Increasing evidence has shown that placental EVs contribute to the regulation of maternal immune and vascular systems during pregnancy via the transfer of their cargos. In this study, we investigated the effect of placental EVs on the growth of opportunistic pathogens that commonly colonise the female reproductive tract.

methodsGram-positive bacterium Group B Streptococcus (GBS) and Gram-negative bacterium Escherichia coli (

resultsWhen treated with placental micro-EVs or nano-EVs, the GBS growth curve entered the stationary phase earlier, compared to untreated GBS. Treatment with placental EVs also inhibited the growth of GBS on solid medium, compared to untreated GBS. However, these biological activities were not seen in

conclusionWe demonstrated the attenuative effect of the growth of GBS treated with placental EVs. Downregulation of cellular components and proteins associated with phosphorylation and cell energy may contribute to the physiological changes in GBS treated with placental EVs.

Indexed as

cell energyGBSplacental EVsprotein synthesisproteomicssusceptibility

Identifiers

PMID34356519
PMCPMC8301483
OpenAlexW3178507496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.