ArticleBiology2021
Third Molar Agenesis Is Associated with Facial Size.
Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- A prospective randomized study on the efficacy of real-time dynamic navigation in deep horizontal mandibular third molar extractions.BMC oral health · 2024Trial
- Association between third molar agenesis and sagittal skeletal discrepancies in an orthodontic patient population.BMC oral health · 2026Article
- Craniofacial size in individuals with supernumerary teeth: A multicenter geometric morphometric study.BMC oral health · 2026Article
- Early radiographic detection and clinical implications of third-molar agenesis in Turkish children and adolescents.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Effect of tooth agenesis on facial soft tissue profile.Scientific reports · 2026Article
- Evaluation and Comparison of Third Molar Agenesis Among Indian and Malaysian Subpopulations: A Retrospective Orthopantomographic Study.Clinical, cosmetic and investigational dentistry · 2026Article
- The effects of environmental stress on third molar agenesis in humans and its population differences.Anthropological science : journal of the Anthropological Society of Nippon = Jinruigaku zasshi · 2026Article
- Influence of Asymmetrical Eruption and Impaction Angulation of the Wisdom Teeth on the Craniofacial Morphology.Cureus · 2026Article
- Palatal canine impaction is not associated with third molar agenesis.European journal of orthodontics · 2025Article
- PITX2 expression and Neanderthal introgression in HS3ST3A1 contribute to variation in tooth dimensions in modern humans.Current biology : CB · 2025Article
- Exploring the Association Between Third Molar Agenesis and Carabelli Traits: A Cross-Sectional Study.Dentistry journal · 2025Article
- Prophylactic third molar removal: are oral surgeons and orthodontists aligned in preventive approaches?BMC oral health · 2024Article
- Occlusal characteristics in modern humans with tooth agenesis.Scientific reports · 2024Article
- Supernumerary Tooth Patterns in Non-Syndromic White European Subjects.Dentistry journal · 2023Article
- Sexual Dimorphism in Third Molar Agenesis in Humans with and without Agenesis of Other Teeth.Biology · 2022Article
- Article
- Agenesis of third molar among the younger population of India born in twenty first century.National journal of maxillofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individuals with congenitally missing permanent teeth, other than third molars, present smaller craniofacial configurations compared to normal controls. However, it is not known if agenesis of third molars is part of the same mechanism. Therefore, this study assessed individuals with and without isolated third molar agenesis and tested the relation of this condition to the size of their facial configurations, using geometric morphometric methods. We show that the absence of one or more third molars is associated with a smaller maxilla, smaller mandible and a smaller overall facial configuration. The effect was larger as the number of missing third molars increased. For example, the size of the mandibular centroids in five 16-year-old females with no, one, two, three or four missing third molars showed a size reduction of approximately 2.5 mm per missing third molar. In addition, in cases with third molar agenesis in one jaw only, the effect was also evident on the opposite jaw. Our findings suggest that isolated third molar agenesis is part of a developmental mechanism resulting also in craniofacial size reduction. This might be the effect of an evolutionary process observed in humans, leading to fewer and smaller teeth, as well as smaller facial structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.