ArticleBiology2021
Effect of Electrical Stimulation on Diabetic Human Skin Fibroblast Growth and the Secretion of Cytokines and Growth Factors Involved in Wound Healing.
Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Making Sense of Electrical Stimulation: A Meta-analysis for Wound Healing.Annals of biomedical engineering · 2024Pooled it
- Ultrasound-activated trilayer piezoelectric bio-adhesive for rapid repair and antibacterial treatment of gastrointestinal perforation.Bioactive materials · 2026Article
- Thermal-feedback modality switchable hydrogel with thermoelectric self-modulation for stage-adaptive repair of infected diabetic wound.Nature communications · 2026Article
- A Data Driven Review of In Vitro Electrical and Mechanical Stimulation for Post-Acute Phase Wound Healing.Advanced healthcare materials · 2026Review
- Electrochemical modulation of host-microbe dynamics in wound healing.Frontiers in microbiology · 2026Review
- Smart Biomaterials in Wound Healing: Advances, Challenges, and Future Directions in Intelligent Dressing Design.Bioengineering (Basel, Switzerland) · 2025Review
- Article
- Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Wound management, healing, and early prosthetic rehabilitation: Part 3 - A scoping review of chemical biomarkers.Canadian prosthetics & orthotics journal · 2025Review
- Electrical stimulation: a novel adjunct therapy for diabetic foot ulcers.Frontiers in clinical diabetes and healthcare · 2025Review
- A quadriphasic mechanical model of the human dermis.Biomechanics and modeling in mechanobiology · 2024Article
- Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation.Life (Basel, Switzerland) · 2024Review
- Wound management, healing, and early prosthetic rehabilitation: Part 1 - A scoping review of healing and non-healing definitions.Canadian prosthetics & orthotics journal · 2024Review
- Molecular Biological Verification of the Healing Effect of Biphasic Microcurrent Electrical Stimulation in Model Rats of Skin Abrasion.Dermatology research and practice · 2024Article
- Programmable Electrochemical Stimulation on a Large-Scale CMOS Microelectrode Array.IEEE Biomedical Circuits and Systems Conference : healthcare technology : [proceedings]. IEEE Biomedical Circuits and Systems Conference · 2022Article
- Engineering diabetic human skin equivalent forFrontiers in bioengineering and biotechnology · 2022Article
- Understanding and utilizing textile-based electrostatic flocking for biomedical applications.Applied physics reviews · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic foot ulcers are indicative of an impaired wound healing process. This delay may be resolved through electrical stimulation (ES). The goal of the present study was to evaluate the effect of ES on diabetic fibroblast adhesion and growth, and the secretion of cytokines and growth factors. Diabetic human skin fibroblasts (DHSF) were exposed to various intensities of direct current ES (100, 80, 40 and 20 mV/mm). The effect of ES on fibroblast adhesion and growth was evaluated using Hoechst staining, MTT and trypan blue exclusion assays. The secretion of cytokine and growth factor was assessed by cytokine array and ELISA assay. The long-term effects of ES on DHSF shape and growth were determined by optical microscopy and cell count. We demonstrated that ES at 20 and 40 mV/mm promoted cell adhesion, viability and growth. ES also decreased the secretion of pro-inflammatory cytokines IL-6 and IL-8 yet promoted growth factor FGF7 secretion during 48 h post-ES. Finally, the beneficial effect of ES on fibroblast growth was maintained up to 5 days post-ES. Overall results suggest the possible use of low-intensity direct current ES to promote wound healing in diabetic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.