Evidence map›Paper›PMID 34356372›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na

Seong-Woo Choi, Ming-Zhe Yin, Na-Kyeong Park, Joo-Han Woo, Sung-Joon Kim

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Seong-Woo ChoiDepartment of Physiology, Dongguk University College of Medicine, Gyeongju 38066, Korea.
Ming-Zhe YinDepartment of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.
Na-Kyeong ParkDepartment of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.
Joo-Han WooDepartment of Physiology, Dongguk University College of Medicine, Gyeongju 38066, Korea.
Sung-Joon KimDepartment of Physiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Funding

National Research Foundation of Korea NRF-2018R1A5A2025964National Research Foundation of Korea NRF-2019R1I1A1A01064006National Research Foundation of Korea NRF-2021R1A2C2007243
6 · The paper itself

Abstract

4-Oxo-nonenal (4-ONE) is an endogenous lipid peroxidation product that is more reactive than 4-hydroxy-nonenal (4-HNE). We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K

Indexed as

4-oxo-nonenalarrhythmiaheartlate Na+ currentlipid peroxidation

Identifiers

PMID34356372
PMCPMC8301175

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.