Evidence map›Paper›PMID 34356342›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Nasal Spray Formulations Based on Combined Hyalurosomes and Glycerosomes Loading

Eleonora Casula, Maria Letizia Manca, Matteo Perra, Jose Luis Pedraz, Tania Belen Lopez-Mendez, Antonio Lozano, Esteban Calvo, Marco Zaru, Maria Manconi

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Liposomal Delivery of a BiotechnologicalAntioxidants (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Review
  7. Design of a Nasal Spray Based onMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Eleonora CasulaDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.
Maria Letizia MancaDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.ORCID 0000-0002-3787-257X
Matteo PerraDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.ORCID 0000-0002-9906-990X
Jose Luis PedrazNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-3938-2267
Tania Belen Lopez-MendezNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), 01006 Vitoria-Gasteiz, Spain.
Antonio LozanoLIFTEC, CSIC-Universidad de Zaragoza, María de Luna 10, 50018 Zaragoza, Spain.ORCID 0000-0003-4141-6072
Esteban CalvoLIFTEC, CSIC-Universidad de Zaragoza, María de Luna 10, 50018 Zaragoza, Spain.
Marco ZaruIcnoderm Srl, Sardegna Ricerche Ed. 5, Pula, 09010 Cagliari, Italy.
Maria ManconiDepartment of Scienze della Vita e dell'Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy.ORCID 0000-0003-4818-2344
University of Cagliari · ITUniversidad de Zaragoza · ESUniversity of the Basque Country · ESSardegna Ricerche (Italy) · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis and rhinosinusitis. It was obtained by combining the strengthening effect of liposomes on barrier function, the hydrating and lubricating properties of sodium hyaluronan and the anti-inflammatory and antioxidant activities of the extract of

Indexed as

antioxidantdroplet sizeepithelial cellsnasal sprayphospholipid vesiclesspray angletraditional medicineZingiber officinalis

Identifiers

PMID34356342
PMCPMC8301047
OpenAlexW3180023588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.