Evidence map›Paper›PMID 34356335›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Urinary Carnosinase-1 Excretion is Associated with Urinary Carnosine Depletion and Risk of Graft Failure in Kidney Transplant Recipients: Results of the TransplantLines Cohort Study.

Angelica Rodriguez-Niño, Diego O Pastene, Adrian Post, M Yusof Said, Antonio W Gomes-Neto, Lyanne M Kieneker, M Rebecca Heiner-Fokkema, Tuba Esatbeyoglu, Gerald Rimbach, Peter Schnuelle and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Angelica Rodriguez-NiñoDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Diego O PasteneDepartment of Nephrology, Endocrinology and Rheumatology (Fifth Department of Medicine), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0002-5955-7335
Adrian PostDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8645-1627
M Yusof SaidDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Antonio W Gomes-NetoDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-4398-4877
Lyanne M KienekerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
M Rebecca Heiner-FokkemaDepartment of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-3477-0770
Tuba EsatbeyogluInstitute of Food Science and Human Nutrition, Gottfried Wilhelm Leibniz University Hannover, 30167 Hannover, Germany.ORCID 0000-0003-2413-6925
Gerald RimbachInstitute of Human Nutrition and Food Science, Christian-Albrechts University of Kiel, 24118 Kiel, Germany.ORCID 0000-0001-7888-4684
Peter SchnuelleDepartment of Nephrology, Endocrinology and Rheumatology (Fifth Department of Medicine), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Benito A YardDepartment of Nephrology, Endocrinology and Rheumatology (Fifth Department of Medicine), Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Stephan J L BakkerDepartment of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791
University Medical Center Groningen · NLHeidelberg University · DEChristian-Albrechts-Universität zu Kiel · DELeibniz University Hannover · DE

Funding

Top Institute Food and Nutrition A-1003
6 · The paper itself

Abstract

Carnosine affords protection against oxidative and carbonyl stress, yet high concentrations of the carnosinase-1 enzyme may limit this. We recently reported that high urinary carnosinase-1 is associated with kidney function decline and albuminuria in patients with chronic kidney disease. We prospectively investigated whether urinary carnosinase-1 is associated with a high risk for development of late graft failure in kidney transplant recipients (KTRs). Carnosine and carnosinase-1 were measured in 24 h urine in a longitudinal cohort of 703 stable KTRs and 257 healthy controls. Cox regression was used to analyze the prospective data. Urinary carnosine excretions were significantly decreased in KTRs (26.5 [IQR 21.4-33.3] µmol/24 h versus 34.8 [IQR 25.6-46.8] µmol/24 h;

Indexed as

carnosinase-1carnosinegraft failurekidney transplantationoxidative stress

Identifiers

PMID34356335
PMCPMC8301129
OpenAlexW3181682534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.