ArticleAntioxidants (Basel, Switzerland)2021
Development and Optimisation of Solid-Phase Extraction of Extractable and Bound Phenolic Acids in Spelt (
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Thermal Processing on the Contents and Bioaccessibility of Polyphenols and Carotenoids in Fresh Waxy Corn.Foods (Basel, Switzerland) · 2026Article
- Extraction Strategy and C18 Solid-Phase Fractionation Shape Phenolic Profiles, Antioxidant Capacity, and Cancer Cell Antiproliferative Activity of Selected Medicinal Plants.Antioxidants (Basel, Switzerland) · 2026Article
- The Metabolic Diversity of DifferentPlants (Basel, Switzerland) · 2026Article
- A deep dive into herbal extraction: Techniques, trends, and technological advancements.South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2026Article
- Exploring the Chemical Composition and Antimicrobial Activity of Extracts from the Roots and Aboveground Parts ofMolecules (Basel, Switzerland) · 2025Article
- Analytics, Properties and Applications of Biologically Active Stilbene Derivatives.Molecules (Basel, Switzerland) · 2023Review
- Identification and Quantification of Selected Benzoxazinoids and Phenolics in Germinated Spelt (Foods (Basel, Switzerland) · 2023Article
- Application of Doehlert Experimental Design for Optimization of a New-Based Hydrophilic Interaction Solid-Phase Extraction of Phenolic Acids from Olive Oils.Molecules (Basel, Switzerland) · 2023Article
- Simulated Gastrointestinal Digestion of Bioprocessed Spelt Seeds: Bioaccessibility and Bioactivity of Phenolics.Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
A solid-phase extraction (SPE) technique was developed and optimised for isolation and concentration of extractable and bound phenolic acids from germinated spelt seeds, for analysis by liquid chromatography-mass spectrometry. Samples initially underwent solvent extraction under different conditions to maximise the yield of phenolic antioxidants. Optimal extraction conditions for extractable phenolics were absolute methanol as solvent, sample-to-methanol ratio 1:9, and reconstitution in non-acidified water. The bound phenolics were extracted from sample pellets using hydrolysis with 2 M NaOH, acidification of the hydrolysate with formic acid, and simultaneous isolation and purification using Strata X polymeric RP tubes. Compared to liquid-liquid extraction, this direct SPE protocol has significant advantages in terms of higher extraction efficiencies of total and individual phenolics and their antioxidant activities. These data suggest that direct SPE represents a rapid and reliable method for quantitative analysis of both the extractable and the commonly overlooked bound phenolics in
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