Evidence map›Paper›PMID 34356287›Full record

ArticleHealthcare (Basel, Switzerland)2021

Influences of Lavender Essential Oil Inhalation on Stress Responses during Short-Duration Sleep Cycles: A Pilot Study.

Wakako Yogi, Mana Tsukada, Yosuke Sato, Takuji Izuno, Tatsuki Inoue, Yoshiki Tsunokawa, Takayuki Okumo, Tadashi Hisamitsu, Masataka Sunagawa

Open access · goldAbstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Review
  2. Relaxation effects of Shikuwasa (Contemporary clinical trials communications · 2026
    Article
  3. A Comprehensive Review on Anxiolytic Effect ofFood science & nutrition · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Protective effect ofIranian journal of basic medical sciences · 2025
    Article
  8. Article
  9. Article
  10. Examination of VOC Concentration of Aroma Essential Oils and Their Major VOCs Diffused in Room Air.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wakako YogiDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Mana TsukadaDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0002-6761-8804
Yosuke SatoDepartment of Neurosurgery, School of Medicine, Showa University, Tokyo 142-8666, Japan.ORCID 0000-0002-3200-4212
Takuji IzunoDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Tatsuki InoueDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Yoshiki TsunokawaDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.
Takayuki OkumoDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0003-4633-6506
Tadashi HisamitsuDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0002-2506-2844
Masataka SunagawaDepartment of Physiology, School of Medicine, Showa University, Tokyo 142-8555, Japan.ORCID 0000-0001-7621-2024
Showa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lavender essential oil (LEO) was reported to improve sleep quality. We investigated the influence of aromatherapy by testing the effects of LEO on stress responses during a short-duration sleep in a single-blind, randomized, crossover trial. The subjects were twelve healthy adults who were nonsmokers without any known disease and who were not prescribed medications, and nine of these completed the study. After the subjects had fallen asleep, they were sprayed with LEO using an aroma diffuser. Before and after 90 min of sleep, α-amylase, chromogranin A (CgA), and cortisol levels in saliva were measured as objective stress indicators, and the Japanese version of the UWIST Mood Adjective Checklist was used as a subjective indicator. A comparison of changes before and after sleep, with and without LEO, revealed that the cortisol level did not significantly change; however, α-amylase (

Indexed as

antistress effectaromatherapychromogranin Acortisollavender essential oilα-amylase

Identifiers

PMID34356287
PMCPMC8303840
OpenAlexW3185805208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.