Evidence map›Paper›PMID 34356182›Full record

ReviewBrain sciences2021

Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review.

Nicola Acevedo, Peter Bosanac, Toni Pikoos, Susan Rossell, David Castle

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  5. Neural basis of successful DBS for OCD after failed capsulotomy.medRxiv : the preprint server for health sciences · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Nicola AcevedoCentre for Mental Health, Swinburne University of Technology, John Street, Melbourne, VIC 3122, Australia.ORCID 0000-0003-3059-3620
Peter BosanacSt. Vincent's Hospital Melbourne, 41 Victoria Parade, Melbourne, VIC 3065, Australia.
Toni PikoosCentre for Mental Health, Swinburne University of Technology, John Street, Melbourne, VIC 3122, Australia.ORCID 0000-0001-7953-9030
Susan RossellCentre for Mental Health, Swinburne University of Technology, John Street, Melbourne, VIC 3122, Australia.
David CastleSt. Vincent's Hospital Melbourne, 41 Victoria Parade, Melbourne, VIC 3065, Australia.
Swinburne University of Technology · AUCentre for Addiction and Mental Health · CASt Vincent's Hospital Melbourne · AUThe University of Melbourne · AU

Funding

Australian Government Research Training Program Scholarship N/AIMPACT philanthropy grant IPAP2017/1439National Health and Medical Research Council GNT1154651
6 · The paper itself

Abstract

Invasive and noninvasive neurostimulation therapies for obsessive-compulsive and related disorders (OCRD) were systematically reviewed with the aim of assessing clinical characteristics, methodologies, neuroanatomical substrates, and varied stimulation parameters. Previous reviews have focused on a narrow scope, statistical rather than clinical significance, grouped together heterogenous protocols, and proposed inconclusive outcomes and directions. Herein, a comprehensive and transdiagnostic evaluation of all clinically relevant determinants is presented with translational clinical recommendations and novel response rates. Electroconvulsive therapy (ECT) studies were limited in number and quality but demonstrated greater efficacy than previously identified. Targeting the pre-SMA/SMA is recommended for transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS). TMS yielded superior outcomes, although polarity findings were conflicting, and refinement of frontal/cognitive control protocols may optimize outcomes. For both techniques, standardization of polarity, more treatment sessions (>20), and targeting multiple structures are encouraged. A deep brain stimulation (DBS) 'sweet spot' of the striatum for OCD was proposed, and CBT is strongly encouraged. Tourette's patients showed less variance and reliance on treatment optimization. Several DBS targets achieved consistent, rapid, and sustained clinical response. Analysis of fiber connectivity, as opposed to precise neural regions, should be implemented for target selection. Standardization of protocols is necessary to achieve translational outcomes.

Indexed as

deep brain stimulation (DBS)electroconvulsive therapy (ECT)neurocircuitryneuromodulationneurostimulationobsessive-compulsive disorder (OCD)transcranial direct current stimulation (tDCS)transcranial magnetic stimulation (TMS)

Identifiers

PMID34356182
PMCPMC8307974
OpenAlexW3183667175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.