Evidence map›Paper›PMID 34356146›Full record

ArticleBrain sciences2021

Gender Differences in Misdiagnosis and Delayed Diagnosis among Adults with Autism Spectrum Disorder with No Language or Intellectual Disability.

Camilla Gesi, Giovanni Migliarese, Sara Torriero, Martina Capellazzi, Anna Caterina Omboni, Giancarlo Cerveri, Claudio Mencacci

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Delayed Diagnosis of Autism Spectrum Disorder in Adolescent Boys.Advances in experimental medicine and biology · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Circadian preference and quality of life in adults with autism spectrum disorder: a Brazilian cross-sectional self-reported survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  7. Sex differences in the global burden of autism spectrum disorders: An analysis based on GBD 2021 data.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Pathways to autism diagnosis in adulthood.Journal of neurodevelopmental disorders · 2025
    Article
  18. Associations Between Social Functioning and Indicators of University Student Engagement.European journal of investigation in health, psychology and education · 2025
    Article
  19. [Advances in research on gender differences in autism spectrum disorders].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Camilla GesiDepartment of Psychiatry and Addiction, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Giovanni MigliareseDepartment of Psychiatry and Addiction, ASST Pavia, 27100 Pavia, Italy.
Sara TorrieroDepartment of Psychiatry and Addiction, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Martina CapellazziSchool of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Anna Caterina OmboniDepartment of Psychiatry and Addiction, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Giancarlo CerveriDepartment of Psychiatry and Addiction, ASST Lodi, 26900 Lodi, Italy.
Claudio MencacciDepartment of Psychiatry and Addiction, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
ASST Fatebenefratelli Sacco · ITAziende Socio Sanitarie Territoriale LodiUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is often unrecognized, especially in mild forms and in women. Studies evaluating features associated with missed/misdiagnosis in men and women with ASD are warranted. 61 subjects (22 females, 39 males, age 28.5 ± 10.8 years) with ASD with no language/intellectual deficit were enrolled in the service for the treatment of psychiatric comorbidities in adults with ASD of the ASST Fatebenefratelli-Sacco in Milan (Italy). A detailed clinical history was gathered, and two self-report questionnaires (Autism Spectrum Quotient-AQ and Adult Autism Subthreshold Spectrum-AdAS Spectrum) were administered. 75.4% received their ASD diagnosis average eight years later than the first evaluation by mental health services. Compared to males, females showed a significantly greater delay in referral to mental health services and a significantly higher age at diagnosis of ASD. Among men, diagnostic delay inversely correlated with scores on the AdAS Spectrum total, Verbal communication, Empathy and Inflexibility and adherence to routine domains. Among women, diagnostic delay positively correlated with the Attention to detail score while the age at diagnosis of ASD positively correlated with the AdAS Spectrum Verbal communication and Restricted interests and rumination domain scores. Females were less likely to be correctly diagnosed and more likely to be misdiagnosed at first evaluation than men. Females reported significantly higher scores than men in the Hyper/Hyporeactivity to sensory input domain only among subjects who were misdiagnosed. Our findings provide gender-specific information about ASD patients seeking help for comorbid conditions and might be a primary ground for future research.

Indexed as

Autism Spectrum DisorderAutism Spectrum Domainscomorbidityfemale phenotypegenderlate diagnosismisdiagnosissensory reactivity

Identifiers

PMID34356146
PMCPMC8306851
OpenAlexW3179002399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.