Evidence map›Paper›PMID 34356125›Full record

ArticleBrain sciences2021

Influenza Vaccine Hesitancy in Patients with Multiple Sclerosis: A Monocentric Observational Study.

Antonio Ziello, Cristina Scavone, Maria Elena Di Battista, Simona Salvatore, Daniele Di Giulio Cesare, Ornella Moreggia, Lia Allegorico, Anna Sagnelli, Stefano Barbato, Valentino Manzo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  14. COVID-19 vaccine hesitancy in Iranian patients with multiple sclerosis.Multiple sclerosis and related disorders · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Antonio ZielloMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Cristina ScavoneDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-9216-922X
Maria Elena Di BattistaMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Simona SalvatoreMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Daniele Di Giulio CesareMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Ornella MoreggiaMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Lia AllegoricoMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
Anna SagnelliNeurological Clinic and Stroke Unit "A. Cardarelli" Hospital, 80131 Naples, Italy.
Stefano BarbatoNeurological Clinic and Stroke Unit "A. Cardarelli" Hospital, 80131 Naples, Italy.
Valentino ManzoNeurological Clinic and Stroke Unit "A. Cardarelli" Hospital, 80131 Naples, Italy.
Annalisa CapuanoDepartment of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giorgia Teresa ManiscalcoMultiple Sclerosis Center "A. Cardarelli" Hospital, 80131 Naples, Italy.
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe so-called "vaccine hesitancy" still represents a common phenomenon that undermines the effectiveness of vaccination campaigns. In 2020, the Italian Medicines Agency recommended to bring forward the flu vaccination campaign, whose importance was also emphasized for patients with Multiple Sclerosis (MS). We aimed to assess vaccination behavior in patients with MS to prepare for the upcoming SARS-CoV-2 vaccination challenge.

methodsThis is an observational study carried out in one MS clinical Centre that enrolled all MS patients who were eligible for any of the flu vaccines recommended by the Italian medicines Agency.

results194 patients were enrolled. Patients' mean age was 43.9 years and 66% were female. Comorbidities, mainly represented by non-autoimmune diseases, were identified in 52% of patients. Almost all patients were receiving a DMT during the study period, mainly dimethyl fumarate, natalizumab, teriflunomide, and interferon. Out of 194 patients, 58.2% accepted to be vaccinated. No statistically significant differences were found, except for the use of natalizumab, which was higher among vaccinated patients.

conclusionThe results of our study emphasize the importance of education and communication campaigns addressed both to healthcare providers and patients with MS, especially considering that MS patients are currently receiving COVID-19 vaccinations.

Indexed as

hesitancyinfluenza vaccinemultiple sclerosisobservational study

Identifiers

PMID34356125
PMCPMC8301852
OpenAlexW3181600500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.