ArticleGenes2021
A Large-Scale Genome-Wide Association Study of Epistasis Effects of Production Traits and Daughter Pregnancy Rate in U.S. Holstein Cattle.
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Genome-Wide Association Study of Daughter Pregnancy Rate in Crossbred Dairy Cows.International journal of molecular sciences · 2025Article
- Investigation of selection signatures of dairy goats using whole-genome sequencing data.BMC genomics · 2025Article
- Uncovering the genetic basis of milk production traits in Mexican Holstein cattle based on individual markers and genomic windows.PloS one · 2025Article
- Computational Identification of Milk Trait Regulation Through Transcription Factor Cooperation in Murciano-Granadina Goats.Biology · 2024Article
- A million-cow genome-wide association study of productive life in U.S. Holstein cows.Genetics, selection, evolution : GSE · 2024Article
- A Million-Cow Validation of a Chromosome 14 Region Interacting with All Chromosomes for Fat Percentage in U.S. Holstein Cows.International journal of molecular sciences · 2024Article
- Large-Sample Genomic Data Mining for Quantitative Traits in U.S. Holstein Cows.Journal of data mining in genomics & proteomics · 2024Article
- Genome-Wide Association Study of Lactation Traits in Chinese Holstein Cows in Southern China.Animals : an open access journal from MDPI · 2023Article
- Genome and chromosome wide association studies for growth traits in Simmental and Simbrah cattle.Animal bioscience · 2023Article
- Multifactorial methods integrating haplotype and epistasis effects for genomic estimation and prediction of quantitative traits.Frontiers in genetics · 2022Article
- Impact of epistasis effects on the accuracy of predicting phenotypic values of residual feed intake in U. S Holstein cows.Frontiers in genetics · 2022Article
- Polymorphisms ofAnimals : an open access journal from MDPI · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epistasis is widely considered important, but epistasis studies lag those of SNP effects. Genome-wide association study (GWAS) using 76,109 SNPs and 294,079 first-lactation Holstein cows was conducted for testing pairwise epistasis effects of five production traits and three fertility traits: milk yield (MY), fat yield (FY), protein yield (PY), fat percentage (FPC), protein percentage (PPC), and daughter pregnancy rate (DPR). Among the top 50,000 pairwise epistasis effects of each trait, the five production traits had large chromosome regions with intra-chromosome epistasis. The percentage of inter-chromosome epistasis effects was 1.9% for FPC, 1.6% for PPC, 10.6% for MY, 29.9% for FY, 39.3% for PY, and 84.2% for DPR. Of the 50,000 epistasis effects, the number of significant effects with log10(1/p) ≥ 12 was 50,000 for FPC and PPC, and 10,508, 4763, 4637 and 1 for MY, FY, PY and DPR, respectively, and A × A effects were the most frequent epistasis effects for all traits. Majority of the inter-chromosome epistasis effects of FPC across all chromosomes involved a Chr14 region containing
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