ArticleGenes2021
Transcriptome-Wide Association Study of Blood Cell Traits in African Ancestry and Hispanic/Latino Populations.
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In one paragraph
Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
–field-weighted citation impact
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Who cites it
10 citing papers in PubMed.
- Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk.Nature genetics · 2025Article
- Polygenic Scores of Cardiometabolic Risk Factors in American Indian Adults.JAMA network open · 2025Article
- Improved multi-ancestry fine-mapping identifiesmedRxiv : the preprint server for health sciences · 2024Article
- A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis.Human genomics · 2024Article
- Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI.Nature communications · 2024Article
- Transcriptome-wide association studies: recent advances in methods, applications and available databases.Communications biology · 2023Review
- Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture.Nature genetics · 2023Article
- MATS: a novel multi-ancestry transcriptome-wide association study to account for heterogeneity in the effects of cis-regulated gene expression on complex traits.Human molecular genetics · 2023Article
- Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.Annals of the rheumatic diseases · 2022Article
- Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Jia WenDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Munan XieDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Bryce RowlandDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jonathan D RosenDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6396-4219
Quan SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8324-2803
Jiawen ChenDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Amanda L TapiaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Huijun QianDepartment of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8171-1378
Madeline H KowalskiDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yue ShanDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kristin L YoungDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Marielisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Maria ArgosDivision of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Stephanie A BienDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Steve BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-8539-5416
Jie YinDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.
Hélène ChoquetDivision of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA.ORCID 0000-0001-9839-8667
Myriam FornageInstitute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX 77030, USA.
Chani J HodonskyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Eric JorgensonRegeneron Genetics Center, Tarrytown, NY 10591, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yongmei LiuMolecular Physiology Institute, Duke University, Durham, NC 27701, USA.
Jee-Young MoonDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0003-3872-7793
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3575-5468
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4032-5745
Lulu ShangDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Tao WangDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Xiang ZhouDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4331-7599
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA 98195, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Yun LiDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MA Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4MCLC NIH HHS 75N90020D00002CLC NIH HHS 75N90020D00003Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS R01 HG010297NHGRI NIH HHS U01 HG007376NHGRI NIH HHS U01 HG007416NHGRI NIH HHS U01 HG007419NHGRI NIH HHS U54 HG003067NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL101250NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL126477NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01 HL135009NHLBI NIH HHS R01 HL141292NHLBI NIH HHS R01 HL149683NHLBI NIH HHS RC1 HL100185NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL120393NIAID NIH HHS 75N93020D00002NIA NIH HHS HHSN271201100004CNIA NIH HHS RC2 AG036607NIA NIH HHS RF1 AG054474NIDA NIH HHS 75N95020D00002NIDA NIH HHS 75N95020D00003NIDA NIH HHS 75N95020D00004NIDA NIH HHS 75N95020D00005NIDA NIH HHS 75N95020D00007NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK101921NIEHS NIH HHS 75N96020D00002NIEHS NIH HHS 75N96020D00003NIGMS NIH HHS R01 GM105785NIH HHS 75N98020D00007NINDS NIH HHS R01 NS041558ORFDO NIH HHS 75N99020D00002ORFDO NIH HHS 75N99020D00003ORFDO NIH HHS 75N99020D00004ORFDO NIH HHS 75N99020D00005ORFDO NIH HHS 75N99020D00006ORFDO NIH HHS 75N99020D00007WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
backgroundThousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematological trait associated variants more common in these populations have likely been missed.
methodsTo derive gene expression prediction models, we used ancestry-stratified datasets from the Multi-Ethnic Study of Atherosclerosis (MESA, including
resultsOur results revealed 24 suggestive signals (
conclusionsThese analyses demonstrate the importance of performing TWAS and other genetic analyses across diverse populations and of balancing sample size and ancestry background matching when selecting a TWAS reference panel.
Indexed as
Genetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociTranscriptomeBlack or African AmericanBlood CellsCohort StudiesGenome-Wide Association StudyHispanic or LatinoHumansPhenotypeWhite Peopleancestryexpression analysisnon-European populationsTWAS (transcriptome-wide association study)
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