Evidence map›Paper›PMID 34356053›Full record

ReviewGenes2021

ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises.

Judith C Birkhoff, Danny Huylebroeck, Andrea Conidi

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Whole Genome Sequencing Reveals amedRxiv : the preprint server for health sciences · 2026
    Article
  7. Article
  8. Article
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  12. Article
  13. Review
  14. Review
  15. Expert consensus on classification and diagnosis of congenital orofacial cleft.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
  16. Identification of the DNA methylation signature of Mowat-Wilson syndrome.European journal of human genetics : EJHG · 2024
    Article
  17. Mowat-Wilson Syndrome: Case Report and Review ofInternational journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Judith C BirkhoffDepartment of Cell Biology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
Danny HuylebroeckDepartment of Cell Biology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0003-4862-1079
Andrea ConidiDepartment of Cell Biology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After its publication in 1999 as a DNA-binding and SMAD-binding transcription factor (TF) that co-determines cell fate in amphibian embryos, ZEB2 was from 2003 studied by embryologists mainly by documenting the consequences of conditional, cell-type specific

Indexed as

AnimalsDisease Models, AnimalEpigenesis, GeneticFaciesGenetic Predisposition to DiseaseHirschsprung DiseaseHumansIntellectual DisabilityMiceMice, KnockoutMicrocephalyMutationPhenotypePluripotent Stem CellsTranscription FactorsZinc Finger E-box Binding Homeobox 2Transcription FactorsZEB2 protein, humanZEB2 protein, mouseZinc Finger E-box Binding Homeobox 2intellectual disabilityMowat-Wilson Syndromeneural crest cellsneurodevelopmentZEB2

Identifiers

PMID34356053
PMCPMC8304685
OpenAlexW3181338938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.