Evidence map›Paper›PMID 34355888›Full record

ArticleAnalytical chemistry2021

Improving the Sensitivity for Quantifying Heparan Sulfate from Biological Samples.

Zhangjie Wang, Vijay M Dhurandhare, Cressida A Mahung, Katelyn Arnold, Jine Li, Guowei Su, Ding Xu, Rob Maile, Jian Liu

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. UtilizingAmerican journal of physiology. Cell physiology · 2025
    Review
  2. Myeloid deficiency of heparan sulfate 6-O-endosulfatases impairs bone marrow hematopoiesis.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. [Advances in heparin structural analysis by chromatography technologies].Se pu = Chinese journal of chromatography · 2023
    Review
  7. Emerging chemical and biochemical tools for studying 3-American journal of physiology. Cell physiology · 2022
    Review
  8. Analysis of 3-Analytical chemistry · 2022
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Zhangjie WangDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
Vijay M DhurandhareDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
Cressida A MahungDepartment of Surgery, North Carolina Jaycee Burn Center, University of North Carolina, Chapel Hill, North Carolina 27599-7050, United States.
Katelyn ArnoldDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
Jine LiDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
Guowei SuDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.
Ding XuDepartment of Oral Biology, School of Dental Medicine, The State University of New York at Buffalo, Buffalo, New York 14214, United States.
Rob MaileDepartment of Surgery, North Carolina Jaycee Burn Center, University of North Carolina, Chapel Hill, North Carolina 27599-7050, United States.
Jian LiuDivision of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States.ORCID 0000-0001-8552-1400
University of North Carolina at Chapel Hill · USUniversity at Buffalo, State University of New York · US

Funding

In vitro synthesis of recombinant heparan sulfateR01HL094463 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN, PAWLINSKI, RAFAL L · 2009 to 2021
$5.2M
TRAUMA RESEARCH FELLOWSHIPT32GM008450 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bruce A Cairns, Anthony G Charles · 1992 to 2026
$3.8M
Developing Heparan Sulfate Glycan ArrayR44GM123792 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI SU, GUOWEI · 2020 to 2021
$2.4M
Reactor for Insect Cell CultureR42GM128484 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI XU, YONGMEI · 2018 to 2020
$1.9M
Heparan Sulfate–Osteoprotegerin Interactions in Bone RemodelingR01AR070179 · NIAMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI XU, DING · 2017 to 2021
$1.7M
Role of extraceullar vesicles in directing immunometabolic homeostasis after burn injuryR01GM131124 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CAIRNS, BRUCE A, MAILE, ROBERT · 2019 to 2022
$1.5M
Synthesis and Pharmacological Evaluation of Homogenous Ultra-Low Molecular Weight HeparinsR01HL144970 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIAN · 2019 to 2021
$946k
Developing Heparan Sulfate Glycan ArrayR41GM123792 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI LIU, JIAN · 2017 to 2018
$297k
Development of heparan sulfate-based therapeutics to treat inflammatory diseasesR43GM144019 · NIGMS · GLYCAN THERAPEUTICS CORPORATION · PI ARNOLD, KATELYN · 2021 to 2021
$231k
NHLBI NIH HHS R01 HL094463NHLBI NIH HHS R01 HL144970NIAMS NIH HHS R01 AR070179NIGMS NIH HHS R01 GM131124NIGMS NIH HHS R41 GM123792NIGMS NIH HHS R42 GM128484NIGMS NIH HHS R43 GM144019NIGMS NIH HHS R44 GM123792NIGMS NIH HHS T32 GM008450
6 · The paper itself

Abstract

Heparan sulfates (HSs) are widely expressed glycans in the animal kingdom. HS plays a role in regulating cell differentiation/proliferation, embryonic development, blood coagulation, inflammatory response, and viral infection. The amount of HS and its structural information are critically important for investigating the functions of HS in vivo. A sensitive and reliable quantitative technique for the analysis of HS from biological samples is under development. Here, we report a new labeling reagent for HS disaccharides analysis, 6-amino-

Indexed as

Heparan SulfateTandem Mass SpectrometryAnimalsBiomarkersChromatography, LiquidDisaccharidesMiceBiomarkersDisaccharidesHeparan Sulfate

Identifiers

PMID34355888
PMCPMC8454094
OpenAlexW3187603120

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.