ArticleMagnetic resonance in medicine2021
NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment.
Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Beyond wound closure: translational opportunities and barriers of mesenchymal stem cells and their extracellular vesicles in burn management.Frontiers in cell and developmental biology · 2026Review
- Neurite orientation dispersion and density imaging in stroke: current applications, limitations, and future directions.Frontiers in human neuroscience · 2026Review
- Associations between temporal lobe cortical NODDI measures and memory function in individuals without clinical dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- MSC-Derived Extracellular Vesicles: Roles and Molecular Mechanisms for Tissue Repair.International journal of nanomedicine · 2025Review
- Moving toward elucidating alternative motor pathway structures post-stroke: the value of spinal cord neuroimaging.Frontiers in neurology · 2024Review
- Nonparametric 5D D-RJournal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Beyond Diffusion Tensor MRI Methods for Improved Characterization of the Brain after Ischemic Stroke: A Review.AJNR. American journal of neuroradiology · 2022Review
- Neurofunctional and neuroimaging readouts for designing a preclinical stem-cell therapy trial in experimental stroke.Scientific reports · 2022Article
- Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells.Frontiers in neurology · 2022Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDiffusion MRI offers insight into ischemic stroke progression in both human and rodent models. However, diffusion MRI to evaluate therapeutic application of mesenchymal stem cells is limited. Robust analytical techniques are required to identify potential physiological changes as a function of cell therapy in stroke. Here, we seek to establish Neurite Orientation Dispersion and Density Imaging (NODDI) as a feasible method in evaluating stroke evolution in response to cell-based therapeutics.
methodsDiffusion MRI data at 21.1T were acquired from 16 male rats. Rats were grouped randomly: naïve (baseline, N = 5), stroke with injections of phosphate buffered saline (N = 6), stroke with injection of 2D human mesenchymal stem cells (hMSC, N = 5). Data were acquired on days 1, 3, 7, and 21 post-surgery. DTI and NODDI maps were generated, with regions of interest placed in the ischemic hemisphere external capsule and striatum. Diffusion parameters were compared between groups each day, and within groups across hemispheres and longitudinally. Behavioral characterizations were on days 0 (pre-surgery), 3, 7, 14, and 21.
resultsThe 2D hMSC preserved diffusional restriction in the external capsule compared to saline (day 1: MD, P = .4060; AD, P = .0220). NODDI indicates that hMSC may have preserved intracellular volume fractions (ICVF: day 1, P = .0086; day 3, P = .0021; day 21, P = .0383). Diffusion metrics of hMSC treated animals were comparable to naïve for the external capsule.
conclusionsNODDI compliments DTI metrics, enhances interpretation of tissue outcome in ischemic stroke following hMSC application, and may be useful in evaluating or predicting therapeutic response.
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Registered trials
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