Evidence map›Paper›PMID 34355695›Full record

ArticleeLife2021

Non-linear dimensionality reduction on extracellular waveforms reveals cell type diversity in premotor cortex.

Eric Kenji Lee, Hymavathy Balasubramanian, Alexandra Tsolias, Stephanie Udochukwu Anakwe, Maria Medalla, Krishna V Shenoy, Chandramouli Chandrasekaran

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
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  8. Review
  9. Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Article
  12. Extracellular Spike Waveforms: Morphology, Biophysics, and Classification Strategies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  13. Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
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  20. Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Eric Kenji LeePsychological and Brain Sciences, Boston University, Boston, United States.ORCID 0000-0002-7166-0909
Hymavathy BalasubramanianBernstein Center for Computational Neuroscience, Bernstein Center for Computational Neuroscience, Berlin, Germany.ORCID 0000-0001-5371-2966
Alexandra TsoliasDepartment of Anatomy and Neurobiology, Boston University, Boston, United States.ORCID 0000-0002-2956-3267
Stephanie Udochukwu AnakweUndergraduate Program in Neuroscience, Boston University, Boston, United States.ORCID 0000-0001-9236-6090
Maria MedallaDepartment of Anatomy and Neurobiology, Boston University, Boston, United States.ORCID 0000-0003-4890-2532
Krishna V ShenoyDepartment of Electrical Engineering, Stanford University, Stanford, United States.ORCID 0000-0003-1534-9240
Chandramouli ChandrasekaranPsychological and Brain Sciences, Boston University, Boston, United States.ORCID 0000-0002-1711-590X
Boston University · USBernstein Center for Computational Neuroscience Berlin · DENeurosciences Institute · US

Funding

Engaging new cognitive and motor signals to improve communication prosthesesR01DC014034 · NIDCD · STANFORD UNIVERSITY · PI JAIMIE M HENDERSON · 2015 to 2026
$8.2M
Understanding the Neural Basis of Volitional State through Continuous Recordings in HumansU01NS098968 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2016 to 2018
$4.7M
Intuitive, complete neural control of tablet computers for communicationU01DC017844 · NIDCD · BROWN UNIVERSITY · PI HOCHBERG, LEIGH R · 2019 to 2025
$4.3M
High-Bandwidth Wireless Interfaces for Continuous Human Intracortical RecordingUH2NS095548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI HOCHBERG, LEIGH R, NURMIKKO, ARTO · 2015 to 2019
$3.7M
Circuit structure and dynamics in prefrontal-limbic networksR01MH116008 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Maria Medalla · 2019 to 2026
$3.7M
Mechanisms underlying extracellular vesicle mediated changes in inflammation, neural circuitry and plasticity following cortical injury in aged monkeysR01AG078460 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI TARA L MOORE, Maria Medalla · 2022 to 2026
$3.2M
Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus MonkeyR01NS122969 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, LUEBKE, JENNIFER I · 2021 to 2025
$3.1M
Toward an Animal Model of Freely Moving HumanDP1HD075623 · NICHD · STANFORD UNIVERSITY · PI SHENOY, KRISHNA V · 2012 to 2013
$1.6M
Organization and Dynamics of Premotor and Prefrontal Cortical Circuits Mediating Goal-Directed BehaviorR00NS092972 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI · 2018 to 2020
$747k
Physiology and structure of prefrontal projections to memory and motor circuitsR00MH101234 · NIMH · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MEDALLA, MARIA · 2015 to 2017
$736k
Organization and Dynamics of Premotor and Prefrontal Cortical Circuits Mediating Goal-Directed BehaviorK99NS092972 · NINDS · STANFORD UNIVERSITY · PI CHANDRASEKARAN, CHANDRAMOULI · 2015 to 2016
$175k
Howard Hughes Medical InstituteNIA NIH HHS R01 AG078460NICHD NIH HHS DP1 HD075623NIDCD NIH HHS R01 DC014034NIDCD NIH HHS U01 DC017844NIMH NIH HHS R00 MH101234NIMH NIH HHS R01 MH116008NINDS NIH HHS K99 NS092972NINDS NIH HHS R00 NS092972NINDS NIH HHS R01 NS122969NINDS NIH HHS U01 NS098968NINDS NIH HHS UH2 NS095548
6 · The paper itself

Abstract

Cortical circuits are thought to contain a large number of cell types that coordinate to produce behavior. Current in vivo methods rely on clustering of specified features of extracellular waveforms to identify putative cell types, but these capture only a small amount of variation. Here, we develop a new method (

Indexed as

Motor CortexAnimalsDecision MakingMacaca mulattaMachine LearningMaleNeural PathwaysNeuronsNonlinear DynamicsSoftwareTask Performance and Analysiscell typescircuitslayersneurosciencenonlinear dimensionality reductionrhesus macaquewaveforms

Identifiers

PMID34355695
PMCPMC8452311
OpenAlexW3189729281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.