ArticleeLife2021
Open access · goldAbstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Phenotypic variability in female individuals with the NAA10 missense variants p.(L126R), p.(L126V), or p.(F128L) leading to NAA10-related syndrome.Molecular and cellular pediatrics · 2026Review
- NAA10 (N-Alpha-Acetyltransferase 10): A Multifunctional Regulator in Development, Disease, and Cancer.Cells · 2025Review
- NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.Redox biology · 2025Article
- Illuminating the impact of N-terminal acetylation: from protein to physiology.Nature communications · 2025Review
- A repository of Ogden syndrome patient derived iPSC lines and isogenic pairs by X-chromosome screening and genome-editing.bioRxiv : the preprint server for biology · 2024Article
- Evaluating possible maternal effect lethality and genetic background effects inbioRxiv : the preprint server for biology · 2024Article
- Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice.PloS one · 2024Article
- Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae.Nature communications · 2023Article
- Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome.European journal of human genetics : EJHG · 2023Article
- Phenotypic variability and gastrointestinal manifestations/interventions for growth in NAA10-related neurodevelopmental syndrome.American journal of medical genetics. Part A · 2023Article
- Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates.International journal of molecular sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 11 institutions in 4 countries.
Hyae Yon Kweon *Department of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.ORCID 0000-0002-1534-0767
Mi-Ni Lee *Department of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.
Max DorfelStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Seungwoon SeoDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.
Leah GottliebDepartment of Chemistry, University of Pennsylvania, Philadelphia, United States.
Thomas PaPazyanStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Nina McTiernanDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0000-0002-1749-6933
Rasmus ReeDepartment of Biomedicine, University of Bergen, Bergen, Norway.
David BoltonDepartment of Molecular Biology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, United States.
Andrew GarciaDepartment of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, United States.
Michael FloryResearch Design and Analysis Service, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, United States.
Jonathan CrainStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Alison SeboldStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Scott LyonsStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Ahmed IsmailStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.
Elaine MarchiDepartment of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, United States.
Seong-Keun SonnDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.
Se-Jin JeongCenter for Cardiovascular Research, Washington University School of Medicine, Saint Louis, United States.ORCID 0000-0002-6375-5334
Sejin JeonDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.ORCID 0000-0002-3819-3421
Shinyeong JuCenter for Theragnosis, Korea Institute of Science and Technology, Seoul, Republic of Korea.ORCID 0000-0001-5483-4690
Simon J ConwayHerman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, United States.
Taesoo KimDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.ORCID 0000-0002-3902-1058
Hyun-Seok KimDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.
Cheolju LeeCenter for Theragnosis, Korea Institute of Science and Technology, Seoul, Republic of Korea.ORCID 0000-0001-8482-4696
Tae-Young RohDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.ORCID 0000-0001-5833-0844
Thomas ArnesenDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Ronen MarmorsteinDepartment of Chemistry, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-4373-4752
Goo Taeg OhDepartment of Life Science and College of Natural Sciences, Ewha Womans University, Seoul, Republic of Korea.ORCID 0000-0002-1104-1698
Gholson J LyonStanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Woodbury, United States.ORCID 0000-0002-5869-0716
Ewha Womans University · KRCold Spring Harbor Laboratory · USNew York State Office for People With Developmental Disabilities · USCancer Research Institute · USUniversity of Bergen · NOHaukeland University Hospital · NOIndiana University School of MedicineKorea Institute of Science and Technology · KRPohang University of Science and Technology · KRThe Graduate Center, CUNY · USWashington University in St. Louis · US
Funding
Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MMolecular Mechanisms, Pathways and Inhibition of Acetyl-Transfer ReactionsR35GM118090 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein · 2016 to 2026
$6.7MPredoctoral Training at the Chemistry-Biology InterfaceT32GM133398 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Ronen Marmorstein, Ernest James Petersson · 2020 to 2026
$2.4MAmino-terminal acetylation of proteins in mammalian biology and diseaseR35GM133408 · NIGMS · INSTITUTE FOR BASIC RES IN DEV DISABIL · PI LYON, GHOLSON · 2019 to 2023
$2.4MCardioprotection and uncoupling myofibroblast-myocyte communicationsR01HL148165 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CONWAY, SIMON JAMES, RUBART-VAN DER LOHE, MICHAEL · 2019 to 2022
$1.6MNCI NIH HHS P30 CA045508NHLBI NIH HHS R01 HL148165NIGMS NIH HHS R35 GM118090NIGMS NIH HHS R35 GM133408NIGMS NIH HHS T32 GM133398
Abstract
Amino-terminal acetylation is catalyzed by a set of N-terminal acetyltransferases (NATs). The NatA complex (including X-linked Naa10 and Naa15) is the major acetyltransferase, with 40-50% of all mammalian proteins being potential substrates. However, the overall role of amino-terminal acetylation on a whole-organism level is poorly understood, particularly in mammals. Male mice lacking
Indexed as
AcetylationAnimalsFemaleMaleMiceMice, KnockoutN-Terminal Acetyltransferase AN-Terminal Acetyltransferase ENaa10 protein, mouseN-Terminal Acetyltransferase AN-Terminal Acetyltransferase Edevelopmental biologyembryonic lethalityhydrocephalymouseNAA10NAA12N-terminal acetylationprotein modification
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.